Two-carbon extension of N,N-disubstituted amides with bis(trimethylsilyl) thioketene affording N,N-disubstituted 3-oxothioamides
N,N-Disubstituted alkanamides cleanly react with bis(trimethylsilyl)thioketene to form N,N-disubstituted 2-trimethylsilyl-3-trimethylsilyloxyalk-2-enethioamides, which upon acid hydrolysis give N,N-disubstituted 3-oxoalkanethioamides.
Direct synthesis of polysubstituted 2-aminothiophenes by Cu(ii)-catalyzed addition/oxidative cyclization of alkynoates with thioamides
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(ii)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere. This journal is