- HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE
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This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular,the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.
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Page/Page column 73; 74
(2019/04/16)
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- The synthesis of 4-benzylamino-6-methyl-1H-pyrrolo[3,2-c]pyridine and 4-benzylamino-6-methyl- 1H-pyrrolo[2,3-b]pyridine
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4-Benzylamino-6-methyl-1H-pyrrolo[3,2-c]pyridine (2) and 4-benzylamino-6-methyl-1H-pyrrolo[2,3-b]pyridine (3) were synthesized as deaza analogues of the anxiolytic agent 4-benzylamino-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (1). The 1-deaza analogue (2) was
- Meade, Eric A.,Beauchamp, Lilia M.
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p. 303 - 308
(2007/10/03)
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