17861-06-2

Basic information

• Product Name: 6-ETHOXYPURINE
• Synonyms: 6-ETHOXYPURINE;6-ethoxy-1h-purin;6-ethoxy-purin;6-ethoxy-1H-purine;6-ETHOXY-2-BROMONAPHTHALENE;6-Ethoxy-9H-purine;6-Ethoxy-7H-purine
• CAS NO: 17861-06-2
• Molecular Formula: C₇H₈N₄O
• Molecular Weight: 164.16
• EINECS: 241-813-2
• Product Categories: Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides
• Mol File: 17861-06-2.mol

Chemical Properties

• Boiling Point: 427.6 °C at 760 mmHg
• Flash Point: 154.2 °C
• Appearance: /
• Density: 1.345 g/cm³
• CAS DataBase Reference: 6-ETHOXYPURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ETHOXYPURINE(17861-06-2)
• EPA Substance Registry System: 6-ETHOXYPURINE(17861-06-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• RTECS: UO8530000
• Hazardous Substances Data: 17861-06-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Ethoxypurine is used as a pharmaceutical intermediate for the synthesis of various drugs targeting different medical conditions.
Used in Cancer Treatment Research:
6-Ethoxypurine is used as a research compound in the development of new cancer treatments, given its potential to contribute to the treatment of various types of cancer.
Used in Gout Treatment Research:
6-Ethoxypurine is used as a research compound in the development of new treatments for gout, potentially offering new therapeutic options for patients.
Used in Neurological Disorder Treatment Research:
6-Ethoxypurine is used as a research compound in the development of new treatments for neurological disorders, exploring its potential to address these conditions.
Used in Antioxidant and Anti-Inflammatory Medication Development:
6-Ethoxypurine is used as a compound in the research and development of new medications with antioxidant and anti-inflammatory properties, which may be beneficial for treating related conditions.

InChI:InChI=1S/C7H8N4O/c1-2-12-7-5-6(9-3-8-5)10-4-11-7/h3-4H,2H2,1H3,(H,8,9,10,11)

Upstream product

• 141-52-6 sodium ethanolate 
• 87-42-3 6-chloro-7H-purine 
• 64-17-5 ethanol 
• 87-42-3 6-chloropurine 
• 4316-98-7 6-chloro-4,5-diaminopyrimidine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 220252-50-6 9-<2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-6-ethoxy-9H-purine 
• 220252-60-8 7-<2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-6-ethoxy-7H-purine 

Relevant articles and documents

An efficient synthesis of substituted cytosines and purines under focused microwave irradiation

A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5-bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99% in?a?short reaction time.

An efficient one-pot synthesis of 6-alkoxy-8,9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N,N-dimethylalkaneamides and alkoxide ions

The synthesis of a number of new 6-alkoxy-8,9-(disubstituted)purines has been accomplished by the cyclization of the corresponding intermediate 5-amino-4-chloro-6-(alkylamino)pyrimidines promoted by alkoxides and various N,N-dimethyl amides, where the latter act as solvent-reagents. By this three-component condensation reaction we are able to introduce an alkyl group in the 8 position of the purine ring with the concomitant nucleophilic replacement of the 6-chloro group with an alkoxy moiety.

N7-DNA: Base-pairing properties of N7-(2'-deoxy-β-d-erythro- pentofuranosyl)-substituted adenine, hypoxanthine, and guanine in duplexes with parallel chain orientation

Oligonucleotides containing N7-(2'-deoxy-β-D-erythro- pentofuranosyl)adenine (1), -hypoxanthine (2), and -guanine (3) were synthesized on solid-phase using phosphonate and phosphoramidite chemistry. As part of the synthesis of compound 2, the nucleobase-anion glycosylation of various 6-alkoxypurines with 2-deoxy-3,5-di-O-(4-toluoyl)-α-D-erythro- pentofuranosyl chloride (5) was investigated. The duplex stability of oligonucleotides containing N7-glycosylated purines opposite to regular pyrimidines was determined, and thermodynamic data were calculated from melting profiles. Oligodeoxyribonucleotide duplexes containing N7- glycosylated adenine. T(d) or N7-glycosylated guanine C(d) base pairs are more stable in the case of parallel strand orientation than in the case of antiparallel chains.