178671-89-1

Basic information

• Product Name: 1,2,5,6,9,9a-hexahydro-3H-Pyrrolo[1,2-a]azepin-3-one
• Synonyms: 1,2,5,6,9,9a-hexahydro-3H-Pyrrolo[1,2-a]azepin-3-one
• CAS NO: 178671-89-1
• Molecular Formula: C9H13NO
• Molecular Weight: 151.20562
• Mol File: 178671-89-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,5,6,9,9a-hexahydro-3H-Pyrrolo[1,2-a]azepin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5,6,9,9a-hexahydro-3H-Pyrrolo[1,2-a]azepin-3-one(178671-89-1)
• EPA Substance Registry System: 1,2,5,6,9,9a-hexahydro-3H-Pyrrolo[1,2-a]azepin-3-one(178671-89-1)

Safety Data

• Hazardous Substances Data: 178671-89-1(Hazardous Substances Data)

Upstream product

• 178671-85-7 5-allyl-1-(but-3-enyl)pyrrolidin-2-one 
• 58805-10-0 N-(3-butenyl)succinimide 
• 58805-13-3 1-(3'-butene-1'-yl)-5-ethoxy-2-pyrrolidinone 
• 80664-36-4 1-(butyl-3-ene-1-yl)-5-hydroxypyrrolidin-2-one 
• 82259-09-4 (racemic)-5-(2'-propenyl)-2-pyrrolidinone 
• 1378306-68-3 (S)-methyl 4-((S)-1,1-dimethylethylsulfinamido)hept-6-enoate 
• 1378307-03-9 (S)-5-allyl-1-(but-3-en-1-yl)pyrrolidin-2-one 
• 82259-09-4 (5S)-(+)-5-(1-Prop-2-enyl)-2-pyrrolidinone 

Relevant articles and documents

Synthesis of 5-Substituted 2-Pyrrolidinones by Coupling of Organozinc Reagents with Cyclic N-Acyliminium Ions

A coupling reaction between cyclic N-acyliminium ions with organozinc reagents is described. The cyclic N-acyliminium ions, generated in situ from N-substituted-5-hydroxy-2-pyrrolidinones by treatment with boron trifluoride-diethyl ether complex or titani

A versatile enantioselective synthesis of azabicyclic ring systems: A concise total synthesis of (+)-grandisine D and unnatural analogues

Closing in on azacines: We have developed a new six step approach for the rapid and enantioselective synthesis of indolizidine, pyrrolo[1,2-a]azepine, and pyrrolo[1,2-a]azocine azabicyclic systems and their respective lactam congeners, which are found in a host of natural products as well as pharmaceutical preparations. This protocol enables a concise enantioselective total synthesis of (+)-grandisine D in 16.4 % overall yield from commercial materials (see scheme). Copyright

β-, γ- and δ-Lactams as conformational constraints in ring-closing metathesis

The azabicycloalkenones 5, 6 and 7 were formed in excellent yields via ring-closing metathesis of the bis-alkenyl precursors 1, 2 and 3.

Ring-closing olefin metathesis for the synthesis of fused nitrogen heterocycles

A novel technique for the efficient synthesis of fused nitrogen heterocycles containing various combinations of five- and eight-membered rings has been developed. This method features the ring-closing metathesis (RCM), which is catalyzed by the molybdenum