178999-42-3

Basic information

• Product Name: 7-Benzothiazolecarboxaldehyde,2,3-dihydro-2-oxo-(9CI)
• Synonyms: 7-Benzothiazolecarboxaldehyde,2,3-dihydro-2-oxo-(9CI)
• CAS NO: 178999-42-3
• Molecular Formula: C₈H₅NO₂S
• Molecular Weight: 179.1958
• Product Categories: BENZOTHIAZOLE
• Mol File: 178999-42-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Benzothiazolecarboxaldehyde,2,3-dihydro-2-oxo-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzothiazolecarboxaldehyde,2,3-dihydro-2-oxo-(9CI)(178999-42-3)
• EPA Substance Registry System: 7-Benzothiazolecarboxaldehyde,2,3-dihydro-2-oxo-(9CI)(178999-42-3)

Safety Data

• Hazardous Substances Data: 178999-42-3(Hazardous Substances Data)

Upstream product

• 178999-37-6 2-Isopropoxy-benzothiazole-7-carbaldehyde 
• 2392-68-9 3-chlorophenyl-isothiocyanate 
• 178999-35-4 N-(3-fluorophenyl)thiocarbamic acid O-(1-methylethyl)ester 
• 178999-36-5 2-methoxybenzothiazole-7-carbaldehyde 
• 20399-33-1 N-(3-chlorophenyl)thiocarbamic acid O-(1-methylethyl)ester 
• 404-72-8 3-fluorophenyl isothiocyanate 

Relevant articles and documents

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

Novel synthesis of benzothiazole derivatives via directed lithiation and aryne-mediated cyclization followed by quenching with electrophiles

A series of benzothiazole derivatives selectively functionalized at position 7 was synthesized in the course of the following one-pot reaction sequence: directed lithiation of 2,2-dimethyl-N-(3-halophenyl)propanethioamides (1, 2) or N-(3-halophenyl)-tert-butylthionocarbamates (15-17), cyclization of the aryne intermediate, and quenching of the resulting aryllithium with selected electrophiles.