20399-33-1Relevant academic research and scientific papers
Novel synthesis of benzothiazole derivatives via directed lithiation and aryne-mediated cyclization followed by quenching with electrophiles
Stanetty, Peter,Krumpak, Barbara
, p. 5130 - 5133 (2007/10/03)
A series of benzothiazole derivatives selectively functionalized at position 7 was synthesized in the course of the following one-pot reaction sequence: directed lithiation of 2,2-dimethyl-N-(3-halophenyl)propanethioamides (1, 2) or N-(3-halophenyl)-tert-butylthionocarbamates (15-17), cyclization of the aryne intermediate, and quenching of the resulting aryllithium with selected electrophiles.
