17918-14-8

Basic information

• Product Name: 2,5-DIMETHOXYBENZOYL CHLORIDE
• Synonyms: 2,5-DIMETHOXYBENZOYL CHLORIDE;2,5-DIMETHOXYBENZENE-1-CARBONYL CHLORIDE;BUTTPARK 48\04-28;2,5-Dimethoxybenzoic acid chloride
• CAS NO: 17918-14-8
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.62
• EINECS: 241-863-5
• Mol File: 17918-14-8.mol

Chemical Properties

• Boiling Point: 179°C/10mm
• Flash Point: 134.1 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 0.000757mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 2,5-DIMETHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYBENZOYL CHLORIDE(17918-14-8)
• EPA Substance Registry System: 2,5-DIMETHOXYBENZOYL CHLORIDE(17918-14-8)

Safety Data

• Hazardous Substances Data: 17918-14-8(Hazardous Substances Data)

Usage

Preparation

AlCl3 (4.0 g, 30 mmol) was suspended in dichloromethane (30 mL). To this mixture, a solution of 1,4- dimethoxybenzene (1.38 g, 10 mmol) and triphosgene (5.94 g, 20 mmol) in dichloromethane (30 mL) was added dropwise over a period of 30 min. The resulting mixture was stirred under reflux for 7 days. It was then poured into crushed ice/ water (50 mL) and stirred with pyridine (0.5 mL) at 0 ℃ for 10 min. The layers were separated and the aqueous phase was extracted with dichloromethane (2 ×20 mL). The combined organic layers were washed with ice-cold 0.5 m HCl (30 mL) and with ice-cold water (2×10 mL), and dried over sodium sulfate. The solvent was evaporated in vacuo and the residue was purified by chromatography on silica gel, eluting with hexane/ethyl acetate (4:1→3:1→2:1→1:1), to afford 1.23 g (60%) of 2,5-dimethoxybenzoyl chloride.

InChI:InChI=1/C9H9ClO3/c1-12-6-3-4-8(13-2)7(5-6)9(10)11/h3-5H,1-2H3

Upstream product

• 2785-98-0 2,5-dimethoxybenzoic acid 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 

Downstream Products

• 42833-59-0 2'-Hydroxy-2,4',5,6'-tetramethoxybenzophenon 
• 42020-21-3 2,5-dimethoxybenzamide 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 17894-37-0 2,5-dimethoxy-benzoic acid anilide 
• 847032-33-1 5,7,2',5'-tetrahydroxyflavone 
• 22961-80-4 2-Hydroxy-2',3,4,5,5',6-hexamethoxybenzophenon 
• 1126079-03-5 N-(3,5-dibromo-4-hydroxyphenyl)-2,5-bis-methoxybenzamide 
• 1424328-63-1 C₁₀H₉NO₃S₂ 
• 351065-79-7 2,5-dimethoxybenzothioamide 
• 1424328-51-7 5-(2,5-dimethoxyphenyl)-1,3,4-oxathiazol-2-one 
• 1027892-25-6 C₁₀H₁₄N₂O₃ 
• 488833-27-8 C₁₀H₁₄N₂O₂S 

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The name of this invention is 2, 5 - dimethoxy-formyl chloride preparation method. The belongs to the technical field of medical technology. The invention the technical problem to be solved in order to involve a more advanced 2, 5 - dimethoxy-formyl chlor