- Quinolines as potent 5-lipoxygenase inhibitors: Synthesis and biological profile of L-746,530
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Leukotriene biosynthesis inhibitors have potential as new therapeutic agents for asthma and inflammatory diseases. A series of novel substituted 2- cyanoquinolines have been synthesized and the structure activity relationships were evaluated with respect
- Dube, Daniel,Blouin, Marc,Brideau, Christine,Chan, Chi-Chung,Desmarais, Sylvie,Ethier, Diane,Falgueyret, Jean-Pierre,Friesen, Richard W.,Girard, Mario,Girard, Yves,Guay, Jocelyne,Riendeau, Denis,Tagari, Philip,Young, Robert N.
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p. 1255 - 1260
(2007/10/03)
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- Bis (biaryl) compounds as inhibitors of leukotriene biosynthesis
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Compounds having the Formula I: STR1 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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