179400-16-9

Basic information

• Product Name: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE
• Synonyms: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE
• CAS NO: 179400-16-9
• Molecular Formula: C₆H₆ClNO₂S
• Molecular Weight: 191.64
• Mol File: 179400-16-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE(179400-16-9)
• EPA Substance Registry System: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE(179400-16-9)

Safety Data

• Hazardous Substances Data: 179400-16-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE is used as a reagent for the synthesis of various pharmaceutical compounds. Its unique chemical properties allow it to be a key component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE is utilized as a reagent in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Dye and Pigment Industry:
5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE is used as an intermediate in the synthesis of dyes and pigments, playing a crucial role in the creation of vibrant colors and shades for various applications.
Used in Organic Compound Production:
As an intermediate, 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE is essential in the production of other organic compounds, expanding its applications across different industries that rely on organic chemistry for their products.

Upstream product

• 18368-58-6 2-mercapto-5-methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 18368-64-4 2-chloro-5-methylpyridine 

Downstream Products

• 179400-53-4 5-methyl-pyridine-2-sulphonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-ylamide 
• 179400-51-2 5-methyl-pyridine-2-sulphonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidin-4-ylamide 
• 51933-81-4 5-methyl-2-phenoxypyridine 
• 251101-37-8 4-(5-methylpyridin-2-yl)morpholine 

Relevant articles and documents

Transition-Metal-Catalyzed Transformation of Sulfonates via S-O Bond Cleavage: Synthesis of Alkyl Aryl Ether and Diaryl Ether

The catalytic conversion of sulfonates, a versatile class of pharmaceutical intermediates, is usually based on C-O bond cleavage. In this paper, however, we discover a rare transformation of sulfonates via S-O bond cleavage catalyzed by transition metal, through which alkyl sulfonates could undergo an intramolecular desulfitative C-O coupling to form aryl alkyl ethers in the presence of a nickel catalyst. Meanwhile, aryl sulfonates perform similarly to give diaryl ethers catalyzed by a palladium complex. This transformation could tolerate a wide range of functionalities. Controlled experiments reveal that the 2-pyridyl group is necessary to promote the reaction as designed. Crossover experiments proved that this transformation might proceed partly in an intermolecular pathway.

Synthesis of sulfonylhydrazone- and acylhydrazone-substituted 8-ethoxy-3-nitro-2h-chromenes as potent antiproliferative and apoptosis inducing agents

3-Nitro-2H-chromenes have recently been identified as a novel class of potent antitumor agents. In view of the favorable effects shown by sulfonylhydrazones and acylhydrazones, we designed and synthesized a series of sulfonylhydrazone- and acylhydrazone-substituted 8-ethoxy-3-nitro-2H-chromene derivatives, and evaluated their cell growth inhibition activities against A549, KG-1, A2780, and K562 cells. All the tested compounds exhibited more potent antiproliferative activity than BENC-511 against KG-1 cells. These compounds displayed IC50 values in the nanomolar range against A2780 cells. Compound 7d showed prominent cytotoxicity against K562 cells with an IC 50 of 0.11 μM, which was comparable to that of BENC-511. Compound 7d arrested K562 cells at the G1 phase at high concentrations and induced apoptosis in K562 cells. Furthermore, 7d increased the levels of cleaved caspase-3, decreased the expression of bcl-2 and induced the cleavage of poly(ADP-ribose) polymerase in K562 cells. Thus, this study provides the development of a series of novel compounds as effective antitumor agents with apoptotic death ability.

SULFONYLAMINO-ACETIC ACID DERIVATIVES

The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from Bosentan

Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows affinities for ET(A) and ET(B) receptors in the low nanomolar range and high functional antagonistic potency in vitro.