A novel synthetic route to morpholin-2,3-diones from 2-aminoalcohols
Reaction of dimethyl acetylenedicarboxylate with 2-aminoalcohols possessing a primary amino group gives 3- methoxycarbonylmethylidinemorpholin-2-ones 5. Subsequent ozonolysis furnishes morpholin-2,3-diones 1 in excellent yields.
Harwood, Laurence M.,Tucker, Toby T.,Angell, Richard,Finch, Harry
p. 4217 - 4220
(2007/10/03)
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