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2-(3-Bromo-4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a 1,3-dioxane ring, a bromo and methoxy substituted phenyl group, and two methyl groups. 2-(3-BroMo-4-Methoxyphenyl)-5,5-diMethyl-1,3-dioxane plays a significant role in the development of new drugs and therapeutic agents.

179942-58-6

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179942-58-6 Usage

Uses

Used in Pharmaceutical Industry:
2-(3-Bromo-4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane is used as a key intermediate in the synthesis of VP 14637 (V785000), a potent inhibitor specifically designed to treat respiratory syncytial virus (RSV) infections. RSV is a common and highly contagious virus that can cause severe respiratory illnesses, particularly in infants, young children, and the elderly. 2-(3-BroMo-4-Methoxyphenyl)-5,5-diMethyl-1,3-dioxane's unique structure allows it to effectively target and inhibit the replication of the virus, providing a valuable treatment option for those affected by RSV infections.
Furthermore, the compound's versatility as a synthetic intermediate makes it a valuable asset in the development of other pharmaceutical agents. Its ability to be modified and incorporated into various drug molecules highlights its potential for use in a wide range of therapeutic applications, from antiviral treatments to other medical conditions that require novel drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 179942-58-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,9,4 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 179942-58:
(8*1)+(7*7)+(6*9)+(5*9)+(4*4)+(3*2)+(2*5)+(1*8)=196
196 % 10 = 6
So 179942-58-6 is a valid CAS Registry Number.

179942-58-6Relevant articles and documents

Dicarbaporphyrinoid systems. Synthesis of oxo-adj-dibenziphlorins

Abusalim, Deyaa I.,Merfeld, Michelle L.,Lash, Timothy D.

, p. 10360 - 10368 (2013/11/06)

A series of diformylbenzophenones were generated by sequentially reacting protected bromobenzaldehydes with n-butyllithium and ethyl N,N- dimethylcarbamate. The acetal protective groups were cleaved with refluxing formic acid. Vilsmeier-Haack formylation of 2,2′,4,4′- tetramethoxybenzophenone also afforded a related dialdehyde. MacDonald "2 + 2" condensation of three benzophenone dialdehydes with a dipyrrylmethane gave oxophlorin analogues constructed from two benzene and two pyrrole rings. The free base oxodibenziphlorins were rather unstable in solution, and in most cases these porphyrinoids were isolated as the corresponding trifluoroacetate salts. The spectroscopic properties of 6-oxo-adj-dibenziphlorins are consistent with a nonaromatic ring system. DFT calculations indicated that the macrocycles considerably diverge from planarity, particularly when methoxy substituents are present on the arene rings.

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

Oost, Thorsten,Backfisch, Gisela,Bhowmik, Swati,Van Gaalen, Marcel M.,Geneste, Herve,Hornberger, Wilfried,Lubisch, Wilfried,Netz, Astrid,Unger, Liliane,Wernet, Wolfgang

scheme or table, p. 3828 - 3831 (2011/08/02)

Herein we report the discovery of a novel series of vasopressin 1b (V1b) receptor antagonists, starting from potent but metabolically labile oxindole SSR149415. Masking the proline N,N-dimethyl amide moiety as an oxazole and attaching a benzylic amine moiety to the northern phenyl ring resulted in potent and selective V1b receptor antagonists with improved metabolic stability and improved pharmacokinetic properties in rat. Compound 18c was found to be efficacious in a rat model of anti-depressant activity.

SUBSTITUTED OXINDOL DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF

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Page/Page column 22, (2010/12/26)

The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments containing said derivatives, and use the

PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES

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Page/Page column 109, (2010/04/30)

The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceut

SUBSTITUTED OXINDOL DERIVATIVES, DRUGS CONTAINING SAID DERIVATIVES AND THE USE THEREOF

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Page/Page column 55, (2008/06/13)

The invention relates to novel oxindol derivative of general formula (I), wherein substituents R1, R2, A, B and Y are such as defined in a claim 1. Drugs containing said derivatives and the use thereof for preventing and/or treating vassopress-and/or oxytocin-dependent-diseases are also disclosed.

Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases

-

, (2008/06/13)

Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

Substituted benzyl pyrimidines

-

, (2008/06/13)

Compounds of the formula: STR1 in which R1 is lower alkoxy, R2 is bromine or lower alkoxy, and R3 is aryl, heteroaryl or a group --Q--R30, wherein Q is ethylene, vinylene or ethynylene and R30 is aryl, heteroaryl, lower alkoxycarbonyl or carbamoyl; hydrolyzable esters of carboxylic acids of formula I; and pharmaceutically acceptable salts of these compounds are useful for treating infectious diseases.

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