17999-93-8

Basic information

• Product Name: 1,1'-Bi[isoquinoline]
• Synonyms: 1,1'-Bi[isoquinoline];1,1'-Biisoquinoline;1,1'-Biisoquinolyl;1,1'-Diisoquinoline;NSC 338038
• CAS NO: 17999-93-8
• Molecular Formula: C₁₈H₁₂N₂
• Molecular Weight: 256.30128
• Mol File: 17999-93-8.mol

Chemical Properties

• Melting Point: 193-194℃ (ethanol )
• Boiling Point: 426.6 °C at 760 mmHg
• Flash Point: 162.3 °C
• Appearance: /
• Density: 1.223 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1,1'-Bi[isoquinoline](CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-Bi[isoquinoline](17999-93-8)
• EPA Substance Registry System: 1,1'-Bi[isoquinoline](17999-93-8)

Safety Data

• Hazardous Substances Data: 17999-93-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1,1'-Bi[isoquinoline] is used as a building block for the synthesis of various organic molecules and pharmaceuticals, leveraging its unique molecular structure to create compounds with potential therapeutic applications.
Used in Anti-inflammatory Applications:
1,1'-Bi[isoquinoline] is utilized for its anti-inflammatory properties, potentially serving as a therapeutic agent to mitigate inflammation in various conditions.
Used in Anti-cancer Applications:
1,1'-Bi[isoquinoline] is explored for its anti-cancer properties, indicating its potential use in developing treatments that target and combat cancer cells.
Used in Organic Light-Emitting Diode (OLED) Materials:
Due to its distinctive molecular structure and properties, 1,1'-Bi[isoquinoline] is investigated for use in OLED materials, which are crucial for the development of advanced display and lighting technologies.
Used in Chemical Research:
1,1'-Bi[isoquinoline] is employed in chemical research to study its potential biological activities and to understand its behavior in various chemical reactions, contributing to the advancement of chemical knowledge and innovation.

Upstream product

• 19658-77-6 1-iodoisoquiniline 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 

Downstream Products

• 1401422-43-2 [Au(1,1'-biisoquinoline)(PPh₃)](CF₃SO₃) 
• 1401422-50-1 [Au(C6F5)]2(μ-1,1'-biisoquinoline) 
• 1401422-51-2 [Au(C₆F₅)(1,1'-biisoquinoline)] 
• 1372897-57-8 [(μ-1,1'-biisoquinoline)2(Ag(ClO4)(PPh3))2] 
• 1372897-59-0 [(μ-1,1'-biisoquinoline)2(Ag(CF3SO3)(PPh2Me))2] 
• 1372897-53-4 [(μ-1,1'-biisoquinoline)(Ag(CF3SO3)(PPh2Me))2] 
• 1372897-52-3 [(μ-1,1'-biisoquinoline)(Ag(CF3SO3)(PPh3))2] 
• 1372897-58-9 [(μ-1,1'-biisoquinoline)2(Ag(ClO4)(PPh2Me))2] 
• 1372897-54-5 [(μ-1,1'-biisoquinoline)(Ag(ClO4)(PPh2Me))2] 

Relevant articles and documents

Studies on Pyrimidine Derivatives. XXXVIII. Cross-Coupling Reaction of N-Heteroaryl Iodides with Ethoxycarbonylmethylzinc Bromide in the Presence of Palladium Catalyst

In the presence of tetrakis(triphenylphosphine)palladium, 2-iodo-4,6-dimethylpyrimidine and 4-iodo-2,6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatsky reagent) to give ethyl 4,6-dimethyl-2-pyrimidineacetate and ethyl 2,6-dimethyl-4-pyrimidineacetate, respectively.In contrast, the reaction of 5-iodo-2,4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide.Similar results were observed in the reactions of various N-heteroaryl iodides.Keywords - Reformatsky reagent; cross-coupling reaction; N-heteroaryl halide; N-heteroarylacetic acid; palladium catalyst; ethyl bromoacetate