180622-24-6

Basic information

• Product Name: Piperazine, 3-methyl-1-(4-methylphenyl)- (9CI)
• Synonyms: Piperazine, 3-methyl-1-(4-methylphenyl)- (9CI)
• CAS NO: 180622-24-6
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28472
• Product Categories: PIPERIDINE
• Mol File: 180622-24-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 3-methyl-1-(4-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 3-methyl-1-(4-methylphenyl)- (9CI)(180622-24-6)
• EPA Substance Registry System: Piperazine, 3-methyl-1-(4-methylphenyl)- (9CI)(180622-24-6)

Safety Data

• Hazardous Substances Data: 180622-24-6(Hazardous Substances Data)

Upstream product

• 106-43-4 para-chlorotoluene 
• 109-07-9 (RS)-2-methylpiperazine 
• 106-38-7 para-bromotoluene 

Downstream Products

• 331767-25-0 9-{4-[4-(4-methyl-phenyl)-3-methyl-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 1134190-89-8 1-(1-benzyl-1,2,3,4-tetrahydroquinolin-6-yloxy)-3-(2-methyl-4-p-tolylpiperazin-1-yl)propan-2-ol 

Relevant articles and documents

Substituted dipeptides having nos inhibiting activity

The present invention a compound represented by the formula (I): where the structural variables R1-R6are defined herein.

Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines

The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.

Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines

A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.