109-07-9

Basic information

• Product Name: 2-Methylpiperazine
• Synonyms: 2-methyl-piperazin;MP;2-METHYLDIETHYLENEDIAMINE;(+/-)-2-METHYLPIPERAZINE;2-METHYLPIPERAZINE;2MPRZ;2-METHYLPIPERAZINE/LOMEFLOXCIN;2-Methylpiperazine ,99%
• CAS NO: 109-07-9
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• EINECS: 203-644-2
• Product Categories: Piperidines, Piperidones, Piperazines;Piperaizine;Piperazine derivates;Piperazines;Building Blocks;Heterocyclic Building Blocks;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 109-07-9.mol

Chemical Properties

• Melting Point: 61-63 °C(lit.)
• Boiling Point: 155 °C763 mm Hg(lit.)
• Flash Point: 149 °F
• Appearance: White to yellow/Crystalline Powder, Crystals and/or Chunks
• Density: 0.817 g/cm
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.4378 (estimate)
• Storage Temp.: Flammables area
• Solubility: 435g/l
• PKA: pK1:5.62(+2);pK2:9.60(+1) (25°C)
• Water Solubility: 78 g/100 mL (25 ºC)
• Sensitive: Air Sensitive & Hygroscopic
• BRN: 383566
• CAS DataBase Reference: 2-Methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylpiperazine(109-07-9)
• EPA Substance Registry System: 2-Methylpiperazine(109-07-9)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36/37/39-36
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 2
• RTECS: TM1225020
• F: 10
• TSCA: Yes
• HazardClass: 4.1
• PackingGroup: III
• Hazardous Substances Data: 109-07-9(Hazardous Substances Data)

Usage

Chemical Properties

white to yellow crystalline powder and chunks

Purification Methods

Purify it by zone melting and by distillation. It is hygroscopic. The picrate has m 275-276o. [Beilstein 23 II 16, 23 III/IV 393, 23/3 V 267.]

InChI:InChI=1/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3

Upstream product

• 109-08-0 2-Methylpyrazine 
• 131543-46-9 Glyoxal 
• 78-90-0 1,2-diaminopropan 
• 57-55-6 propylene glycol 
• 107-15-3 ethylenediamine 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 4526-77-6 3-methylpiperazine-2,5-dione 
• 123-91-1 1,4-dioxane 
• 123-84-2 N-(2-hydroxypropyl)ethylenediamine 
• 3138-90-7 3-methyl-1-(phenylmethyl)piperazine 
• 56-81-5 glycerol 
• 50-99-7 D-glucose 
• 57-50-1 Sucrose 

Downstream Products

• 110331-69-6 2-(3-methyl-piperazino)-1,1-diphenyl-ethanol 
• 22316-97-8 3-Methyl-piperazin-1-dithiocarbonsaeure 
• 5472-83-3 4-(3-methyl-piperazino)-butan-1-ol 
• 90152-49-1 3-methylpiperazine-1-carboxylic acid ethyl ester 
• 6320-20-3 3-(3-methyl-piperazino)-propan-1-ol 
• 102179-89-5 2-methyl-1,4-bis-(1-nitro-cyclohexylmethyl)-piperazine 
• 109-08-0 2-Methylpyrazine 
• 3477-42-7 1-(2-hydroxyethyl)-2-methylpiperazine 
• 59215-34-8 2-(3-methyl-piperazin-1-yl)-pyrimidine 
• 152943-96-9 1-(2-Methoxyphenyl)-3-methylpiperazine 
• 120737-59-9 3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 104794-87-8 1-(4-Acetamido-3-nitrobenzoyl)-3-methylpiperazine 
• 93107-32-5 CNV97100 
• 98079-51-7 lomefloxacin 

Related news

Design, synthesis, and biological evaluation of novel 2-Methylpiperazine (cas 109-07-9) derivatives as potent CCR5 antagonists08/22/2019

Three series of novel 2-methylpiperazine derivatives were designed and synthesized using a fragment-assembly strategy. Among them, six compounds (13, 16, 18, 22, 33, and 36) showed potent activity against CCR5 comparable to that of the positive control, maraviroc, in calcium mobilization assay. ...detailed

Theoretical study of CO2 separation from CO2/CH4 gaseous mixture using 2-Methylpiperazine (cas 109-07-9) -promoted potassium carbonate through hollow fiber membrane contactor08/20/2019

With increasing of worldwide demand for natural gas, as one of the primary energy sources, the separation of CO2 from raw natural gas streams has caught high attention. Hollow fiber membrane contactors (HFMC) are known as the potential gas-liquid contactor for removal of CO2. In such systems, th...detailed

Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology

A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols, and diamines lead to heterocyclic ring systems.

Production of phenylpiperazines

PROBLEM TO BE SOLVED: To provide a method for selectively producing piperazines with high yield.SOLUTION: Vicinal diamines and vicinal diols are subject to dehydrative cylization reaction in the presence of a Raney metal catalyst and a dehydration agent.

METHOD FOR PRODUCING AMINES FROM GLYCERIN

The present invention relates to a process for preparing amines by reacting glycerol with hydrogen and an aminating agent from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 0.01 to 40 MPa (from 0.1 to 400 bar). Preference is given to using glycerol based on renewable raw materials. The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use. This invention further provides the compounds 1,2,3-triaminopropane, 2-aminomethyl-6-methylpiperazine, 2,5-bis(aminomethyl)piperazine and 2,6-bis(aminomethyl)piperazine.

METHOD FOR PRODUCING AMINES FROM SUGAR ALCOHOLS

The present invention relates to a process for preparing amines by reacting sugar alcohols with hydrogen and an aminating agent selected from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 1 to 40 MPa (from 10 to 400 bar). The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The sugar alcohol is preferably obtained by hydrogenating the corresponding sugars. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use.

PROCESS FOR PRODUCING NITROGENOUS HETEROCYCLIC COMPOUND

A nitrogenous heterocyclic compound such as 3-aminopyrrolidine derivative is produced by hydrogenolysis of an N-substituted nitrogenous heterocyclic compound with normal pressure hydrogen in a water-based solvent in presence of a catalyst. In the case an optically active 1-substituted-3-aminopyrrrolidine derivative is used as a raw material, an optically active 3-aminopyrrolidine derivative can be obtained as a product practically without racemination.

Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

This invention relates to compounds of Formula I STR1 which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.

8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof

The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) STR1 in which X1, X2, R1 and R2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones

This invention relates to compounds of Formula I STR1 which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibitors of platelet aggregation.

2-SUBSTITUTED N,N'-DITRIMETHOXYBENZOYL PIPERAZINES AND THERAPEUTIC COMPOSITIONS CONTAINING THEM

This invention relates to piperazine derivatives of the general formula I STR1 wherein--(CH 2) n--represents a straight or branched chain alkyl group having from n=1 to n=20 carbon atoms, and R represents a hydrogen atom, a branched alkyl group, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.