180698-18-4

Basic information

• Product Name: 1-(2-Biphenyl)Piperazine 2Hcl
• Synonyms: 1-biphenyl-2-yl-piperazine;1-(2-biphenyl)piperazine;1-(2-diphenyl)piperazine;1-(2-biphenylyl)piperazine;1-(biphenyl-2-yl)piperazine
• CAS NO: 180698-18-4
• Molecular Formula: C16H18N2
• Molecular Weight: 238.332
• Mol File: 180698-18-4.mol

Chemical Properties

• Melting Point: 149 °C
• Boiling Point: 413.4±33.0 °C(Predicted)
• Density: 1.068±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(2-Biphenyl)Piperazine 2Hcl(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Biphenyl)Piperazine 2Hcl(180698-18-4)
• EPA Substance Registry System: 1-(2-Biphenyl)Piperazine 2Hcl(180698-18-4)

Safety Data

• Hazardous Substances Data: 180698-18-4(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
1-(2-Biphenyl)Piperazine 2Hcl is used as a reactant for the synthesis of aralkyl piperazine derivatives, which are essential in the development of new pharmaceutical compounds. These derivatives have potential applications in the treatment of various medical conditions, including neurological disorders and psychiatric illnesses, due to their ability to modulate specific receptors in the central nervous system.
2. Used in Chemical Research:
In the field of chemical research, 1-(2-Biphenyl)Piperazine 2Hcl serves as a valuable starting material for the synthesis of various compounds containing substituted aryl-piperazines and piperidines. These compounds are of interest to researchers due to their diverse chemical properties and potential applications in various industries, such as materials science, agrochemistry, and environmental science.
3. Used in the Synthesis of Compounds with Specific Applications:
1-(2-Biphenyl)Piperazine 2Hcl is also used in the synthesis of compounds with specific applications in various industries. For example, some of the synthesized aralkyl piperazine derivatives may have potential uses as agrochemicals, such as pesticides or herbicides, due to their ability to target specific pests or weeds. Additionally, these compounds may also find applications in the development of new materials with unique properties, such as improved conductivity or enhanced mechanical strength.

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 90-41-5 2-phenylaniline 
• 583-53-9 2,3-dibromobenzene 
• 494773-35-2 4-(2-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1052401-87-2 N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide 
• 1414941-70-0 1-(4-methoxyphenoxy)-3-[4-(2-biphenyl)piperazin-1-yl]propan-2-ol 
• 1607802-81-2 3-[4-(2-biphenyl)piperazin-1-yl]-1-phenoxy-2-propanol 
• 1610849-04-1 3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-cyanophenyl)methyl]propanamide 
• 1253936-76-3 C₃₁H₃₆N₄O₅ 
• 1253935-99-7 4-amino-N-[2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]-3-methoxy-benzamide 
• 1253936-07-0 isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide 
• 1610849-05-2 3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide 

Relevant articles and documents

PYRIDAZINONES AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Br?nsted Acid Mediated Cascade Reaction to Access 3-(2-Bromoethyl)benzofurans

A unified protocol for the construction of 3-(2-bromoethyl)benzofurans and 2-(benzofuran-3-yl)ethylamines from bis[(trimethylsilyl)oxy]cyclobutene has been developed. This mild and facile strategy was applied for the synthesis of a series of 5-HT serotonin receptor agonists, underlining its potential for the syntheses of bioactive compounds and natural products.

NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.

NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE

Pharmaceiiticai compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

A versatile and practical microwave-assisted synthesis of sterically hindered N-arylpiperazines

A wide-ranging and practical synthesis of structurally diverse, sterically hindered N-arylpiperazines from 2,2′-(4-nitrophenylsulfonylazanediyl) bis(ethane-2,1-diyl) bis(4-nitrobenzenesulfonate) and substituted anilines has been achieved using microwave i

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype- selective antagonists by functional in vitro screening. 3-[4-(ortho- Substituted phenyl)piperazin-1:yl]propylamines were derivatized with N,N- dimethyl anthranilamides, nicotinamides, as well as carboxamides of quinoline, 1,8-naphthyridine, pyrazolo[3,4-b]pyridine, isoxazolo[3,4- b]pyridine, imidazo[4,5-b]pyridine, and pyrazolo[1,5-a]pyrimidines. Strips of rabbit bladder neck were employed as a predictive assay for antagonism in the human lower tract. Rings of rat aorta were used as a 'negative screen' for the test antagonists. Binding to α1-ARs was relatively sensitive to size and electronic features of the arylpiperazine portion of the antagonists and permissive to these features on the heteroaryl carboxamide side. These structure-affinity findings were exploited to produce nicotinamides (e.g. 13ii and 25x) and pyrazolo[3,4-b]pyridines (e.g. 37f and 37y) ligands with nanomolar affinity at the α1-AR subtype prevalent in the human lower urinary tract (pA2 values: 8.8, 10.7, 9.3, and 9.9, respectively) and displaying 2-3 orders of magnitude selectivity over the α(1D)-AR.