- Mono- and bi-nuclear ruthenium(II) complexes containing a new asymmetric ligand 3-(pyrazin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline: Synthesis, characterization and DNA-binding properties
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A novel asymmetric ligand 3-(pyrazin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline (pztp) and its mono- and bi-nuclear complexes [Ru(bpy)2(pztp)]2+ 1 and [(bpy)2Ru(pztp)Ru(bpy)2]4+ 2 (bpy = 2,2′-bipyridine) have been synthesized and characterized by UV/VIS, IR, 1H NMR and mass spectra. The electrochemical behaviours of complexes 1 and 2 were observed and displayed oxidation potentials at 1.37 and 1.39 and 1.60 V vs. saturated calomel electrode, respectively. The binding of the two complexes with calf thymus DNA has also been investigated by a spectrophotometric method and viscosity measurements. The results indicated that the two complexes interact with DNA in sharply different ways. The mononuclear complex 1 intercalates into DNA base pairs despite its small hypochromicity value, while the binuclear complex 2 binds to DNA via electrostatic interaction. The circular dichroism signals of the dialysates of the racemic complexes against calf thymus DNA are discussed.
- Zou, Xiao-Hua,Ye, Bao-Hui,Li, Hong,Liu, Jin-Gang,Xiong, Ya,Ji, Liang-Nian
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- Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines
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The reaction of multidentate pyrazine based ligands was explored towards Cp*rhodium and Cp*iridium precursors. Mononuclear and dinuclear complexes formed by the ratio-based reaction between ligand and metal precursor. The representative complexes have been determined by single crystal X-ray diffraction studies. Cytotoxicity study of the ligands and their complexes are evaluated against human colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53?/? and ARPE-19 (non-cancer retinal epithelium) cells. Complexes 2-5 and 7-8 were cytotoxic to cells and although the potency of these complexes was less than cisplatin, selectivity towards cancer cell lines as opposed to non-cancer ARPE-19 cells was comparable to cisplatin. From in-vitro cytotoxicity studies complexes 4 and 5 demonstrated good selectivity towards HCT116 p53?/? cells suggesting that these complexes are promising leads for the treatment of p53 deficient cancers.
- Lapasam, Agreeda,Pinder, Emma,Phillips, Roger M.,Kaminsky, Werner,Kollipara, Mohan Rao
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- ANTI-BACTERIAL COMPOUNDS
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Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).
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Page/Page column 35
(2008/06/13)
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- Discovery of a potent phenolic N1-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria
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As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.
- Rathbone, Daniel L.,Parker, Katy J.,Coleman, Michael D.,Lambert, Peter A.,Billington, David C.
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p. 879 - 883
(2007/10/03)
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