18107-03-4

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 

Downstream Products

• 1257421-73-0 5,6-bis[(E)-2-(3,4-dimethoxyphenyl)vinyl]-3-pyrazin-2-yl-1,2,4-triazine 
• 1257421-72-9 5,6-bis[(E)-2-(4-methoxyphenyl)vinyl]-3-pyrazin-2-yl-1,2,4-triazine 
• 1257421-71-8 5,6-bis[(E)-2-phenylvinyl]-3-pyrazin-2-yl-1,2,4-triazine 
• 883051-25-0 C₁₁H₁₁N₅O₂S 
• 1254358-33-2 C₁₂H₉N₅O₂S 
• 1351754-71-6 C₁₂H₁₃N₅O₂S 
• 3458-03-5 5-pirazynylo-1,2,4-triazolo-3-tiol 

Relevant academic research and scientific papers

Mono- and bi-nuclear ruthenium(II) complexes containing a new asymmetric ligand 3-(pyrazin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline: Synthesis, characterization and DNA-binding properties

A novel asymmetric ligand 3-(pyrazin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline (pztp) and its mono- and bi-nuclear complexes [Ru(bpy)2(pztp)]2+ 1 and [(bpy)2Ru(pztp)Ru(bpy)2]4+ 2 (bpy = 2,2′-bipyridine) have been synthesized and characterized by UV/VIS, IR, 1H NMR and mass spectra. The electrochemical behaviours of complexes 1 and 2 were observed and displayed oxidation potentials at 1.37 and 1.39 and 1.60 V vs. saturated calomel electrode, respectively. The binding of the two complexes with calf thymus DNA has also been investigated by a spectrophotometric method and viscosity measurements. The results indicated that the two complexes interact with DNA in sharply different ways. The mononuclear complex 1 intercalates into DNA base pairs despite its small hypochromicity value, while the binuclear complex 2 binds to DNA via electrostatic interaction. The circular dichroism signals of the dialysates of the racemic complexes against calf thymus DNA are discussed.

Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

The reaction of multidentate pyrazine based ligands was explored towards Cp*rhodium and Cp*iridium precursors. Mononuclear and dinuclear complexes formed by the ratio-based reaction between ligand and metal precursor. The representative complexes have been determined by single crystal X-ray diffraction studies. Cytotoxicity study of the ligands and their complexes are evaluated against human colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53?/? and ARPE-19 (non-cancer retinal epithelium) cells. Complexes 2-5 and 7-8 were cytotoxic to cells and although the potency of these complexes was less than cisplatin, selectivity towards cancer cell lines as opposed to non-cancer ARPE-19 cells was comparable to cisplatin. From in-vitro cytotoxicity studies complexes 4 and 5 demonstrated good selectivity towards HCT116 p53?/? cells suggesting that these complexes are promising leads for the treatment of p53 deficient cancers.

Discovery of a potent phenolic N1-benzylidene- pyridinecarboxamidrazone selective against Gram-positive bacteria

As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.

ANTI-BACTERIAL COMPOUNDS

Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).