- Total Synthesis of Naphterpin and Marinone Natural Products
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A concise and divergent strategy for the synthesis of the naphterpin and marinone meroterpenoid families has been developed. The approach features a succession of pericyclic reactions-an aromatic Claisen rearrangement, a retro-6?€-electrocyclization, and
- Murray, Lauren A. M.,Fallon, Thomas,Sumby, Christopher J.,George, Jonathan H.
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- Diene-Transmissive Diels-Alder Sequences with Benzynes
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Diene-transmissive Diels-Alder (DTDA) sequences are extraordinarily powerful processes for the generation of fused bicyclic systems. Nonetheless, only stable dienophiles have previously been deployed. Herein we report DTDA sequences with a variety of substituted [3]dendralenes in the first study to deploy arynes as dienophiles. We demonstrate the one-flask generation of complex, aromatic-ring-containing, multicyclic systems of relevance to medicinal chemistry. These synthetic operations provide numerous successful examples of the otherwise challenging and rarely reported intermolecular Diels-Alder reaction of acyclic 1,3-butadienes with arynes, which is made possible due to the exalted reactivity of dendralenic dienes.
- George, Josemon,Ward, Jas S.,Sherburn, Michael S.
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- Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone
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A concise route toward two advanced fragments in the context of the total synthesis of the unique natural product azamerone is reported. Key synthetic features include the enantioselective synthesis of an epoxysilane and its Lewis-acid-induced cyclization and the installation of the pyridazine ring via a formylation/condensation sequence. This route provides strategic insights into the chemistry of phthalazinediols, facilitating synthetic approaches toward this class of natural products.
- Schnell, Simon D.,Linden, Anthony,Gademann, Karl
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supporting information
p. 1144 - 1147
(2019/05/16)
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- Structure Elucidation of the Main Tetrahydroxyxanthones of Hypericum Seeds and Investigations into the Testa Structure
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Seeds from Hypericum species have recently been identified as an interesting source of xanthone derivatives. Extraction of seeds from H. perforatum with MeOH and subsequent concentration via polyamide adsorption yielded a fraction enriched in tetrahydroxy
- Lorenz, Peter,Heller, Annerose,Bunse, Marek,Heinrich, Miriam,Berger, Melanie,Conrad, Jürgen,Stintzing, Florian C.,Kammerer, Dietmar R.
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- A catalytic oxidation fragrant boron class compound preparing phenol method (by machine translation)
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The invention discloses a method for catalytic oxidation of phenolic compounds fragrant boron class compound synthesis method, the flux in the solvent in the aqueous solution, under the action of alkali, adding hydrazine hydrate or acid hydrazides catalyst, catalytic oxidation fragrant boron class compound directly for the preparation of phenolic compound. The invention of the method of preparation of the phenol compound, the catalyst is a cheap hydrazine hydrate or hydrazine compound, the oxidizing agent is atmospheric pressure of air or oxygen, the reaction does not need good and activeness metal catalyst, is extensive and stable substrate, substrate-sensitive functional group compatibility good and wide range of application. In the optimized under the reaction conditions, the yield of the target product separation up to 99%. (by machine translation)
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Paragraph 0024; 0045; 0046
(2017/08/08)
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- Synthesis and Evaluation of Novel 7- and 8-Aminophenoxazinones for the Detection of β-Alanine Aminopeptidase Activity and the Reliable Identification of Pseudomonas aeruginosa in Clinical Samples
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A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their corresponding β-alanine derivatives were synthesized and evaluated for their ability to detect β-alanyl aminopeptidase activity in bacteria known to hydrolyze β-ala
- Bedernjak, Alexandre F.,Zaytsev, Andrey V.,Babolat, Michèle,Cellier, Marie,James, Arthur L.,Orenga, Sylvain,Perry, John D.,Groundwater, Paul W.,Anderson, Rosaleen J.
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p. 4476 - 4487
(2016/06/13)
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- Model Studies towards Functionalized Bisbenzannulated [5,6]-Spiroketals
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Following up on our previous model studies on the synthesis of simple bisbenzannulated [5,6]-spiroketals we here report the preparation of new examples of this entity with a variation in their substitution pattern. The regioselective introduction of functional groups in the C-3 or C-3′ positions (rubromycin numbering) may either take place prior to the spiroketalization by α-functionalizations of the ketone moiety of the precursor or in a subsequent step by the nucleophilic substitution of the benzylic hydroxy group of the previously described C-3-hydroxylated spiroketal. By applying these methods we could synthesize new methyl-substituted, hydroxylated, halogenated and amino-substituted bisbenzannulated [5,6]-spiroketals in good overall yields. C-1 or C-3? By applying suitable methods new functionalized [5,6]-spiroketals were regioselectively generated as model compounds for rubromycin-type natural products.
- Wilsdorf, Michael,Lentz, Dieter,Reissig, Hans-Ulrich
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p. 1555 - 1561
(2016/04/05)
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- Unexpected hydrazine hydrate-mediated aerobic oxidation of aryl/ heteroaryl boronic acids to phenols in ambient air
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The expedient and efficient sub-stoichimetric hydrazine hydrate-mediated aerobic hydroxylation of boronic acids that proceeds in poly(ethylene glycol) (PEG-400) has been successfully developed, providing diverse phenols in high yields. And heteroaryl boronic acids are also amenable to this protocol. the Partner Organisations 2014.
- Zhong, Yanzhen,Yuan, Linxin,Huang, Zheng,Gu, Wenchao,Shao, Ye,Han, Wei
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p. 33164 - 33167
(2014/08/18)
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- Synthetic models related to methoxalen - CYP2A6 interactions. Dimethoxybenzofuran derivatives as potent and selective inhibitors of cyp2a6
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The human CYP2A6 enzyme metabolizes several xenobiotics including nicotine, the addictive component in tobacco. Reduced activity of CYP2A6, either for genetic reasons or by administering inhibitors of CYP2A6, reduces tobacco smoking. The reported compound
- Yamaguchi, Yuki,Akimoto, Ichie,Motegi, Kyoko,Yoshimura, Teruki,Wada, Keiji,Nishizono, Naozumi,Oda, Kazuaki
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p. 1727 - 1739
(2013/09/12)
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- Synthesis of phenols via fluoride-free oxidation of arylsilanes and arylmethoxysilanes
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Rapid, efficient methods have been developed to prepare phenols from the oxidation of arylhydrosilanes. The effects of arene substituents and fluoride promoters on this process show that while electron-deficient arenes can undergo direct oxidation from the hydrosilane, electron-rich aromatics benefit from silane activation via oxidation to the methoxysilane using homogeneous or heterogeneous transition metal catalysis. The combination of these two oxidations into a streamlined flow procedure involving minimal processing of reaction intermediates is also reported.
- Rayment, Elizabeth J.,Summerhill, Nick,Anderson, Edward A.
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experimental part
p. 7052 - 7060
(2012/10/07)
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- Attempts directed towards the synthesis of intermediate (aryne)chromium complexes from aryl triflates and from (haloarene)chromium complexes
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The generation of (I·6-aryne)chromium complexes as reactive intermediates was investigated in two ways. Although earlier attempts directed towards triflate eliminations from a variety of tricarbonyl(phenyl triflate)chromium complexes had failed, more electron-rich phenyl triflate complexes were considered. This was accomplished either by substitution with two methoxy groups in the arene ligand or by replacement of one of the three carbonyl ligands of the tricarbonylchromium complex with triphenylphosphane. However, the attempted elimination still did not take place; in spite of the increased electron densities in the aromatic ligands, anionic thia-Fries rearrangements were observed in high yields at -78 °C. As an alternative, elimination of lithium fluoride was tested. Tricarbonyl(2-lithiofluorobenzene) chromium(0) was generated by tin/lithium exchange. After hydrolytic workup, tricarbonyl(fluorobenzene)chromium was obtained as the main product, indicating that the lithiation step had been successful. A dimeric side product provided evidence for the intermediacy of (benzyne)tricarbonylchromium. Copyright
- Werner, Georg,Butenschoen, Holger
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p. 3132 - 3141
(2012/06/30)
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- Biomimetic synthesis of the apoptosis-inducing thiazinoquinone thiaplidiaquinone A
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A concise total synthesis of the apoptosis-inducing, marine metabolite thiaplidiaquinone A is described. The key ring forming steps are both based on biosynthetic considerations and involve the construction of the central benzo[c]chromene quinone unit by an extremely facile oxa-6π-electrocyclic ring closure reaction of an ortho-quinone intermediate, derived by tautomerization of a bis-benzoquinone, readily accessed from two simple phenolic precursors. This is followed by the installation of the 1,4-thiazine-dioxide ring by reaction of the benzo[c]chromene quinone with hypotaurine.
- Carbone, Anna,Lucas, Catherine L.,Moody, Christopher J.
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p. 9179 - 9189
(2013/01/15)
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- Anodic coupling of guaiacol derivatives on boron-doped diamond electrodes
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The anodic treatment of guaiacol derivatives on boron-doped diamond electrodes (BDD) provides a direct access to nonsymmetrical biphenols, which would require a multistep sequence by conventional methods. Despite the destructive nature of BDD anodes they
- Kirste, Axel,Schnakenburg, Gregor,Waldvogel, Siegfried R.
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supporting information; experimental part
p. 3126 - 3129
(2011/08/03)
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- Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity
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Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.
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Page/Page column 19
(2009/12/07)
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- Process for the preparation of substituted phenols
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A substituted phenolic compound is prepared by oxidizing a substituted diarylethane compound with oxygen in the presence of a nitrogen-containing cyclic compound, and treating the oxidized product with an acid. The nitrogen-containing cyclic compound includes, as a constituent of its ring, a skeleton represented by following Formula (I): wherein X is oxygen atom or an -OR group, where R is hydrogen atom or a hydroxyl-protecting group. The substituted diarylethane compound is represented by following Formula (1): wherein each of Ring Ar1 and Ring Ar2 is independently a monocyclic or polycyclic aromatic carbocyclic ring; Y1 is an electron-donating group; Y2 is an electron-withdrawing group; "p" is an integer of 1 or more; and "q" is an integer of 0 or more. The substituted phenolic compound is represented by following Formula (2): wherein Ring Ar1, Y1, and "p" are as defined above.
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(2008/12/08)
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- HYDROQUINONE LONG-CHAIN DERIVATIVE AND/OR PHENOXY LONG-CHAIN DERIVATIVE, AND PHARMACEUTICAL PREPARATION COMPRISING THE SAME
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The present invention provides compounds represented by formula (1) shown below: (wherein R1, R2, R3, R4, and R5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R6, R7, R8, R9, and R10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group).The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.The present invention provides compounds represented by formula (1) shown below: (wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R 6 , R 7 , R 8 , R 9 , and R 10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group). The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.
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Page/Page column 18
(2008/06/13)
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- Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth
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Following the promising activity of Q2FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a SN2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q2FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q2FA15 allowing the conception of new hybrid compounds is also described.
- Hanbali, Mazen,Bagnard, Dominique,Luu, Bang
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p. 3917 - 3920
(2007/10/03)
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- Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4] benzoquinone
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A telescoped process for the preparation of 2-methoxy-3-methyl-[1,4] benzoquinone is disclosed. When this novel process is compared to the prevailing method that utilizes Na2Cr2O7 as the oxidant, the novel process represen
- Rodriguez Gonzalez, Raquel,Gambarotti, Cristian,Liguori, Lucia,Bjorsvik, Hans-Rene
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p. 1703 - 1706
(2007/10/03)
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- Synthesis of novel organoselenium as catalyst for Baeyer-Villiger oxidation with 30% H2O2
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A novel diselenide was synthesized in good yield via only four steps from phenol, and was employed as the catalyst for the Baeyer-Villiger oxidation with 30% H2O2 to obtain lactones in good yields.
- Ichikawa, Hayato,Usami, Yoshihide,Arimoto, Masao
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p. 8665 - 8668
(2007/10/03)
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- Regioselective synthesis of the bridged tricyclic core of Garcinia natural products via intramolecular aryl acrylate cycloadditions
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(equation presented) Two different routes to the tricyclic core of Garcinia-derived natural products are described. The first approach is based on a tandem Claisen/ Diels-Alder rearrangement and delivers the desired lactone 14. The second approach, employ
- Tisdale, Eric J.,Chowdhury, Chinmay,Vong, Binh G.,Li, Hongmei,Theodorakis, Emmanuel A.
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p. 909 - 912
(2007/10/03)
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- SAR studies of 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one as inhibitors of 4-hydroxyphenylpyruvate dioxygenase
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Various 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one 1 derivatives have been synthesized and tested as inhibitors of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver. The inhibition results indicated that well-positioned dicarbonyl groups as well as the cyclopropyl group of 1 were essential for potent inhibition. Substitution at the 2-position of the ring system has a significant effect on inhibitor potency, while the 5-position can undergo substantial variations and retain inhibitor potency. In the compounds examined, 2-chloro substituted 12 is the best inhibitor of all with IC50 of 15 nM, the rest of the synthesized analogues were less potent inhibitors than the parent compound.
- Lin, Yung-Lung,Wu, Chung-Shieh,Lin, Shean-Woei,Huang, Jian-Lin,Sun, Yang-Sheng,Yang, Ding-Yah
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p. 685 - 690
(2007/10/03)
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- Selenium(IV) oxide catalyzed oxidation of aldehydes to carboxylic acids with hydrogen peroxide
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A convenient method for oxidative transformation of aromatic, heteroaromatic and aliphatic aldehydes into carboxylic acids is presented. It is based on the oxidation of aldehydes in THF using 30% hydrogen peroxide in the presence of 5 molar % of selenium(IV) oxide. The scope and limitation of the method are discussed.
- Brzaszcz,Kloc,Maposah,Mlochowski
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p. 4425 - 4434
(2007/10/03)
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- Synthesis of the bisbenzannelated spiroketal core of the γ-rubromycins. The use of a novel Nef-type reaction mediated by Pearlman's catalyst
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The synthesis of the bisbenzannelated spiroketal core 6 of γ-rubromycin 1 from the substituted nitrostyrene 20 was achieved by using a novel Nef-type reaction mediated by Pearlman's catalyst. The precursor 28 was synthesised from readily prepared starting materials using Henry condensation chemistry. The product 6 was found to exist in two conformations in solution as shown by NMR spectroscopy.
- Capecchi, Tanya,De Koning, Charles B.,Michael, Joseph P.
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p. 2681 - 2688
(2007/10/03)
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- Studies on quinones. Part. 33. Synthetic approach to podands containing quinone fragments
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The preparation and oxidative demethylation attempts of podands 3-5, and 9 containing the 2,5-dimethoxyphenyl substituent are described. The reaction of alizarine 13 with chloroethanol afforded compounds 14 and 15. The pathway formation of heterocycle 15 from 14 is proposed. The synthesis of podand 16 containing the cytotoxic 1-hydroxy-9,10-anthraquinone fragment as the terminal groups is reported.
- Valderrama, Jaime A.,Leiva, Hilda,Tapia, Ricardo
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p. 737 - 749
(2007/10/03)
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- Method for the production of alkoxy- and aryloxy-phenols
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Alkoxybenzaldehydes and aryloxybenzaldehydes are converted to the corresponding phenols by reacting the benzaldehydes in an organic solvent phase with formic acid and hydrogen peroxide in an aqueous solvent phase to produce the corresponding formate ester. The formate ester is then saponified to produce the corresponding phenol.
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- Baeyer-Villiger oxidation of β-aryl substituted unsaturated carbonyl compounds with hydrogen peroxide and catalytic selenium dioxide
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A simple and cheap oxidative procedure using 30% H2O2 and catalytic SeO2 allows to transform 2-aralkylidenecycloalkanones and hydroxy- or alkoxybenzaldehydes to give, in high yields, enollactones and arylformates, respectively.
- Guzman,Mendoza,Garcia,Garibay,Oliveras,Maldonado
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p. 2121 - 2133
(2007/10/02)
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- Mechanistic Studies of Selective Catechol Formation from o-Methoxyphenols using a Copper(II)-Ascorbic Acid-Dioxygen System
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Mechanistic details of selective conversion of o-methoxyphenols to the corresponding catechols using a Cu2+-ascorbic acid-O2 system, were studied. 2,5-Dimethoxyphenol was converted predominantly to the o-demethylated compound and partially to the m-demethylated one.Anisole with no phenolic hydroxy group was much less reactive.When guaiacol (1). guaiacol and 2-methoxy-6-methoxyphenol was used as substrates, moderate intermolecular and intramolecular kinetic isotope effects were observed (1.4-1.9). Catechol was derived from 1 in nine-fold excess over catechol when the reaction was run in an 18O2 atmosphere with natural water as a solvent, though no catechol was formed when using natural O2 and H218O.It was determined that the Cu2+-ascorbic acid-O2 system operates in a monooxygenase mode because the oxygen atom of dioxygen (not water) was incorporated into the products, and this oxidative conversion proceeded mainly via ipso-substitution at the methoxy position, probably with hydroxyl radical coordinated to the cupric ion as the active oxygen species.
- Aihara, Kazuhiro,Urano, Yasuteru,Higuchi, Tsunehiko,Hirobe, Masaaki
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p. 2165 - 2170
(2007/10/02)
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- Studies of Chromenes. Part 9. Syntheses of Chromenequinones
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Syntheses of 2,2-dimethylchromene-5,8-quinone, 2,2-dimethylchromene-6,7-quinone, and 6,7-dimethoxy-2,2-dimethylchromene-5,8-quinone are described.Being easily bioreductible to electron-rich chromenes these compounds, and their oxirane derivatives, are of
- Brown, Philip E.,Lewis, Robert A.,Waring, Mark A.
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p. 2979 - 2988
(2007/10/02)
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- The Baeyer-Villiger Oxidation of Aromatic Aldehydes and Ketones with Hydrogen Peroxide Catalyzed by Selenium Compounds
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A series of organoselenium compounds was investigated as activators of hydrogen peroxide in the Baeyer-Villiger oxidation.As a result, a convenient and cheap method for transformation of aromatic aldehydes, having polycondensed ring systems or electron-donating substituents, and polymethoxy derivatives of acetophenone, into phenols was elaborated.This method utilizes hydrogen peroxide activated by areneseleninic acids, as oxidizing agent.
- Syper, Ludwik
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p. 167 - 172
(2007/10/02)
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- ISOLATION, STRUCTURE AND SYNTHESIS OF MAESANIN, A HOST DEFENSE STIMULANT FROM AN AFRICAN MEDICINAL PLANT MAESA LANCEOLATE
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The isolation, characterization and an efficient synthesis of maesanin 1, a host defense stimulant isolated from an African medicinal plant Maesa lanceolate, is reported.
- Kubo, Isao,Kim, Mujo,Ganjian, Iraj,Kamikawa, Tadao,Yamagiwa, Yoshiro
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p. 2653 - 2660
(2007/10/02)
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- Synthesis of Halodimethoxy-1,2-benzoquinones
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Syntheses of a large number of halodimethoxy-1,2-benzoquinones are described.A key reaction in these syntheses is the chlorination of methoxy-1,2-benzoquinones upon treatment with tert-butyl hypochlorite.
- Wriede, Ulrich,Fernandez, Mario,West, Kevin F.,Harcourt, Dale,Moore, Harold W.
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p. 4485 - 4489
(2007/10/02)
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- Electrophilic Hydroxylation with Bis(trimethylsilyl)peroxide. A Synthon for the Hydroxyl Cation
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The regiospecific introduction of an hydroxy group in aromatic and aliphatic compounds can be performed in good yields by electrophilic hydroxylation of their organometallic derivatives with bis(trimethylsilyl)peroxide.
- Taddei, Maurizio,Ricci, Alfredo
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p. 633 - 635
(2007/10/02)
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- APPLICATION OF LINEAR FREE ENERGY RELATIONSHIPS (LFER) IN THE AROMATIC HYDROXYLATION OF ANISOPLES BY CHROMIC ACID IN ACETIC ACID - WATER MIXTURES
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Kinetics and mechanism of aromatic hydroxylation of anisoles by chromic acid has been investigated in 50percent aqueous acetic acid.The reaction followed secod order kinetics, first order each in and at constant and ionic strength.The effect of meta and para substituents on the reaction rates has been studied.The application of LFER to the rates reveals that the site of attack is at the ortho carbon atom but not at the oxygen atom.
- Reddy, P. Musala,Jagannadham, V.,Sethuram, B.,Rao, T. Navaneeth
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p. 115 - 118
(2007/10/02)
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- An Improved Synthesis of 1,4-Benzo- and 1,4-Naphthoquinones Bearing Active Substituents
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The synthesis of 1,4-benzoquinones and 1,4-naphthoquinones 3a-j carrying substituents such as methoxyl, allyl or oxiranyl was substantially improved.The 1-methoxy-4-methoxymethyloxy 2a-d, g-k or 1,4-bis(methoxymethyloxy) derivatives 2e-f were used, as a substrates instead of 1,4-dimethoxy derivatives 1a-j hitherto used and they were oxidized with silver(II) dipicolinate.Among numerous examples, the synthesis of a new analog of ubiquinone 3d with the oxiranyl substituent, being a new bioactivated alkylating agent, is reported.
- Syper, Ludwik,Kloc, Krystian,Mlochowski, Jacek
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p. 808 - 822
(2007/10/02)
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- SELECTIVE DEALKYLATIONS OF ARYL ALKYL ETHERS AND THIOETHERS BY SODIUM IN HMPA
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The reaction of sodium with bis- and tris(alkoxy)benzenes in HMPA gives selectively the products of monodealkylation.The reaction proceeds through a dianion which fragments into an alkyl and an aryloxy anion.The positional selectivity of this fragmentation is governed by the structure of both the alkyl and aryloxy groups.With bis- and tris(alkoxy)benzenes which for symmetry reasons can afford aryloxy anions having the same basicity, the dealkylation involves exlusively the less substituted alkyl group.On the contrary, in the asymmetric terms, the positional selectivity of the dealkylation process is governed by the basicity of the aryloxy anion.On the basis of these concepts several efficient and synthetically useful reactions have been developed.In most cases the selectivity obtained in the present reactions in different from that observed with other previously developed methods which use sodium methoxide or sodium alkenethiolates in HMPA.It is shown that the appropriate choice of the reagent allows selective dealkylation of the desired alkoxy group of a poly(alkoxy)benzene.The reaction of sodium with bis(alkylthio)benzenes in HMPA gives the bis(mercapto)benzenes.If the reduction is carried out with a solution of sodium in HMPA, the reaction gives instead the products of monodealkylation.This however is not selective.It is suggested that in the case of thioethers the dealkylation products originate from the fragmentation of the radical anions.
- Testaferri, L.,Tiecco, M.,Tingoli, M.,Chianelli, D.,Montanucci, M.
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p. 3687 - 3692
(2007/10/02)
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- Phytochemistry of Genus Gentiana. XXVI. Identification of a New Di-O-glucosyl Cinnamoyl-C-glucosylflavone in the Leaves of Gentiana X marcailhouana RY.
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A new di-O-glucosyl cinnamoyl-C-glucosylflavone has been identified as 4'-O-β-D-glucosyl-2''-O-isoorientin (1).
- Luong, Minh Duc,Saeby, Jan,Fombasso, Pierre,Jacot-Guillarmod, Andre
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p. 2741 - 2745
(2007/10/02)
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