181284-94-6

Basic information

• Product Name: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate
• Synonyms: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate;3-Amino-4-methyl-benzo[b]thiophene-2-carboxylicacidethylester
• CAS NO: 181284-94-6
• Molecular Formula: C12H13NO2S
• Molecular Weight: 235.31
• Mol File: 181284-94-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate(181284-94-6)
• EPA Substance Registry System: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate(181284-94-6)

Safety Data

• Hazardous Substances Data: 181284-94-6(Hazardous Substances Data)

Upstream product

• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 623-51-8 ethyl 2-sulfanylacetate 
• 1885-76-3 2-cyano-3-nitrotoluene 

Downstream Products

• 1427420-56-1 C₂₁H₂₃NO₅S 

Relevant articles and documents

Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b] thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents

Two new series of inhibitors of tubulin polymerization based on the 2-(alkoxycarbonyl)-3-(3′,4′,5′-trimethoxyanilino)benzo[b] thiophene and thieno[2,3-b]pyridine molecular skeletons were synthesized and evaluated for antiproliferative activity on a panel

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)

Benzimidazole derivative

The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Benzimidazole derivatives

A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: 1wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents —COOR3, —SO3R3, —CONHR3 or —SO2NHR3, etc., G represents an alkylene group, M represents a single bond or —S(O)m. J represents a heterocyclic group, and X represents —CH= or a nitrogen atom.

BENZIMIDAZOLE DERIVATIVES

A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents -COOR3, -SO3R3, -CONHR3 or -SO2NHR3, etc., G represents an alkylene group, M represents a single bond or -S(O)m-, J represents a heterocyclic group, and X represents -CH= or a nitrogen atom.