6575-09-3

Basic information

• Product Name: 2-CHLORO-6-METHYLBENZONITRILE
• Synonyms: 2-CHLORO-6-METHYLBENZONITRILE;2-CHLORO-6-TOLUNITRILE;6-CHLORO-O-TOLUNITRILE;BUTTPARK 121\11-43;2-Cyano-3-chlorotoluene;o-Tolunitrile, 6-chloro-;3-chloro-2-toluonitrile;2-Chloro-6-methylbenzonitrile,97%
• CAS NO: 6575-09-3
• Molecular Formula: C₈H₆ClN
• Molecular Weight: 151.59
• EINECS: 229-499-5
• Product Categories: Aromatic Nitriles
• Mol File: 6575-09-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 79-81 °C(lit.)
• Boiling Point: 143 °C38 mm Hg(lit.)
• Flash Point: 143°C/38mm
• Appearance: /
• Density: 1.1976 (rough estimate)
• Vapor Pressure: 0.0367mmHg at 25°C
• Refractive Index: 1.5660 (estimate)
• Storage Temp.: Refrigerator (+4°C)
• BRN: 2246414
• CAS DataBase Reference: 2-CHLORO-6-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYLBENZONITRILE(6575-09-3)
• EPA Substance Registry System: 2-CHLORO-6-METHYLBENZONITRILE(6575-09-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21
• Safety Statements: 23
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6575-09-3(Hazardous Substances Data)

Usage

Chemical Properties

light cream to light brown fine crystalline powder

Uses

FT-IR spectrum of 2-chloro-6-methylbenzonitrile has been studied in the region 400-4000cm-1 by KBr pellet technique.

InChI:InChI=1/C8H6ClN/c1-6-3-2-4-8(9)7(6)5-10/h2-4H,1H3

Upstream product

• 151-50-8 potassium cyanide 
• 87-63-8 2-chloro-6-methylaniline 
• 1885-76-3 2-cyano-3-nitrotoluene 
• 5100-98-1 1-chloro-2-iodo-3-methylbenzene 
• 529-19-1 2-Methylbenzonitrile 
• 56043-01-7 2-amino-6-methylbenzonitrile 

Downstream Products

• 84328-67-6 2-Methyl-6-(2,2,2-trifluoro-ethoxy)-benzonitrile 
• 93085-97-3 2-Methyl-6-butyloxy-benzonitril 
• 17511-23-8 6-chloro-2-methyl-3-nitrobenzonitrile 
• 74671-11-7 2-chloro-6-methyl-3-nitrobenzonitrile 
• 1194-64-5 2-chloro-6-methylbenzaldehyde 
• 77532-86-6 2-chloro-6-formylbenzonitrile 
• 861308-97-6 2-chloro-6-chloromethyl-benzonitrile 
• 101080-58-4 2-chloro-6-methylbenzamide 
• 941594-51-0 2-(3-benzyloxy-4-nitrobenzyl)-6-methylbenzonitrile 
• 808133-91-7 1-(4-methoxyphenyl)-1-(2-methyl-6-piperidin-1-ylphenyl)methylamine 
• 808133-90-6 1-(2-methyl-6-piperidin-1-yl-phenyl)-1-phenyl-methylamine 
• 808133-89-3 2-ethyl-6-piperidin-1-ylbenzonitrile 
• 1417917-21-5 2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-benzonitrile 

Relevant articles and documents

Method for preparing polysoproxil intermediate

The method comprises the following steps: (1). A hydrogen chloride salt of 2 - chlorine -6 - methylaniline compound 1 is prepared by taking 2 - chlorine -6 - methylaniline compound 1 as a raw material in a suitable solvent, and then subjected to diazotization reaction with a nitration reagent aqueous solution to obtain the diazonium salt 2 - chloro -6 - methylaniline. The iodine-containing reagent is reacted with an iodo reagent to obtain 3 -chloro -2 -iodotoluene compound 2. (2), the compound 2 is reacted with the reactant cyanide to give 2 -chloro -6 -iodo-benzonitrile compound 3. (3), the compound 3 undergoes a hydrolysis reaction to obtain 2 - chloro -6 - methyl benzoic acid compound 4, and the reaction equation is as follows. The method has the advantages of cheap and easily available raw materials, high reaction conversion rate, simplicity and rapidness, mild and controllable reaction conditions, mild reaction conditions, high yield of the obtained product, easy separation and purification, high purity and easy industrial mass production.

1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives

Derivatives of 1,3-dihydro-3-(2-hydroxyethyl) -2H-isoindol-1-one are disclosed. The derivatives are useful for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric or hydrochloric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.