- Cyano-containing chlorosilane synthesis method
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The invention belongs to the field of organosilicon materials and discloses a cyano-containing chlorosilane synthesis method. The cyano-containing chlorosilane synthesis method includes adding copper chloride, a tertiary amine derivative and cyano-containing olefins into a reactor, dropwise adding hydrogen-containing chlorosilane with stirring under protection of nitrogen at 0-10 DEG C, heating to reach 50-120 DEG C after dropwise adding, conducting holding reaction for 3-48 hours, cooling to a room temperature after reaction is completed, and collecting corresponding fractions through reduced-pressure distillation so as to obtain cyano-containing chlorosilane. The cyano-containing chlorosilane compound is synthesized by addition reaction between the cyano-containing olefins and the hydrogen-containing chlorosilane with the copper chloride as a main catalyst and the tertiary amine derivative as a cocatalyst by means of dropwise adding under the mild conditions. The cyano-containing chlorosilane synthesis method has the advantages of high efficiency, high product selectivity, safe and mild reaction conditions, simple and easily available catalysts and low cost.
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Paragraph 0031; 0032
(2017/08/29)
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- Rhenium-mediated dehydrogenative silylation and highly regioselective hydrosilylation of nitrile substituted olefins
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The rhenium (I) complex [Re(CH3CN)3Br 2(NO)] catalyzes the homogeneous hydrosilylation of a variety of substituted acrylonitriles, which were converted into the corresponding silyl-substituted alkanes with high regioselectivity of up to 94%. The products were analyzed by 1H NMR and GC-MS. A rhenium specific mechanism is proposed for the hydrosilylation of olefins.
- Dong, Hailin,Jiang, Yanfeng,Berke, Heinz
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- Steroidal Silicon Side-Chain Analogues as Potential Antifertility Agents
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A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized.Particularly noteworthy are a group of estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity.The best compounds synthesized are 17α-estradiol (5) and 17α-estradiol (33), which show a separation of antifertility from estrogenic activity in the rat.The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.
- Peters, Richard H.,Crowe, David F.,Tanabe, Masato,Avery, Mitchell A.,Chong, Wesley K. M.
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p. 646 - 652
(2007/10/02)
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