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18163-33-2

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18163-33-2 Usage

General Description

3-[chloro(dimethyl)silyl]propanenitrile, also known as DMCN, is a chemical compound with the molecular formula C6H11ClNSi. It is a nitrile containing a chloro(dimethyl)silyl group attached to a propyl chain. DMCN is commonly used as a reagent in organic synthesis reactions, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. It can also be used as a building block in the preparation of various pharmaceutical and agrochemical products. DMCN is flammable and may release dangerous fumes when heated, so it should be handled with care in a well-ventilated area.

Check Digit Verification of cas no

The CAS Registry Mumber 18163-33-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,6 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 18163-33:
(7*1)+(6*8)+(5*1)+(4*6)+(3*3)+(2*3)+(1*3)=102
102 % 10 = 2
So 18163-33-2 is a valid CAS Registry Number.

18163-33-2Downstream Products

18163-33-2Relevant articles and documents

Cyano-containing chlorosilane synthesis method

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Paragraph 0031; 0032, (2017/08/29)

The invention belongs to the field of organosilicon materials and discloses a cyano-containing chlorosilane synthesis method. The cyano-containing chlorosilane synthesis method includes adding copper chloride, a tertiary amine derivative and cyano-containing olefins into a reactor, dropwise adding hydrogen-containing chlorosilane with stirring under protection of nitrogen at 0-10 DEG C, heating to reach 50-120 DEG C after dropwise adding, conducting holding reaction for 3-48 hours, cooling to a room temperature after reaction is completed, and collecting corresponding fractions through reduced-pressure distillation so as to obtain cyano-containing chlorosilane. The cyano-containing chlorosilane compound is synthesized by addition reaction between the cyano-containing olefins and the hydrogen-containing chlorosilane with the copper chloride as a main catalyst and the tertiary amine derivative as a cocatalyst by means of dropwise adding under the mild conditions. The cyano-containing chlorosilane synthesis method has the advantages of high efficiency, high product selectivity, safe and mild reaction conditions, simple and easily available catalysts and low cost.

Steroidal Silicon Side-Chain Analogues as Potential Antifertility Agents

Peters, Richard H.,Crowe, David F.,Tanabe, Masato,Avery, Mitchell A.,Chong, Wesley K. M.

, p. 646 - 652 (2007/10/02)

A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized.Particularly noteworthy are a group of estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity.The best compounds synthesized are 17α-estradiol (5) and 17α-estradiol (33), which show a separation of antifertility from estrogenic activity in the rat.The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.

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