18163-33-2

Usage

Uses

Used in Organic Synthesis:
3-[chloro(diMethyl)silyl]propanenitrile is used as a reagent for the formation of carbon-carbon and carbon-nitrogen bonds in organic synthesis reactions. Its unique structure allows for the creation of various complex organic molecules.
Used in Pharmaceutical and Agrochemical Production:
3-[chloro(diMethyl)silyl]propanenitrile serves as a building block in the preparation of pharmaceutical and agrochemical products. Its ability to form essential bonds makes it a valuable component in the synthesis of active ingredients for drugs and pesticides.
Safety Considerations:
Due to its flammable nature, 3-[chloro(diMethyl)silyl]propanenitrile may release dangerous fumes when heated. It is crucial to handle 3-[chloro(diMethyl)silyl]propanenitrile with care in a well-ventilated area to ensure safety during its use in various applications.

Upstream product

• 917-54-4 methyllithium 
• 1071-22-3 2-cyanoethyltrichlorosilane 
• 1066-35-9 dimethylmonochlorosilane 
• 107-13-1 acrylonitrile 

Relevant academic research and scientific papers

Cyano-containing chlorosilane synthesis method

The invention belongs to the field of organosilicon materials and discloses a cyano-containing chlorosilane synthesis method. The cyano-containing chlorosilane synthesis method includes adding copper chloride, a tertiary amine derivative and cyano-containing olefins into a reactor, dropwise adding hydrogen-containing chlorosilane with stirring under protection of nitrogen at 0-10 DEG C, heating to reach 50-120 DEG C after dropwise adding, conducting holding reaction for 3-48 hours, cooling to a room temperature after reaction is completed, and collecting corresponding fractions through reduced-pressure distillation so as to obtain cyano-containing chlorosilane. The cyano-containing chlorosilane compound is synthesized by addition reaction between the cyano-containing olefins and the hydrogen-containing chlorosilane with the copper chloride as a main catalyst and the tertiary amine derivative as a cocatalyst by means of dropwise adding under the mild conditions. The cyano-containing chlorosilane synthesis method has the advantages of high efficiency, high product selectivity, safe and mild reaction conditions, simple and easily available catalysts and low cost.

Rhenium-mediated dehydrogenative silylation and highly regioselective hydrosilylation of nitrile substituted olefins

The rhenium (I) complex [Re(CH3CN)3Br 2(NO)] catalyzes the homogeneous hydrosilylation of a variety of substituted acrylonitriles, which were converted into the corresponding silyl-substituted alkanes with high regioselectivity of up to 94%. The products were analyzed by 1H NMR and GC-MS. A rhenium specific mechanism is proposed for the hydrosilylation of olefins.

Steroidal Silicon Side-Chain Analogues as Potential Antifertility Agents

A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized.Particularly noteworthy are a group of estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity.The best compounds synthesized are 17α-estradiol (5) and 17α-estradiol (33), which show a separation of antifertility from estrogenic activity in the rat.The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.