181641-61-2

Basic information

• Product Name: 1-(BENZYLOXYCARBONYL)-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID
• Synonyms: 4-phenyl-1-phenylmethoxycarbonylpiperidine-4-carboxylic acid
• CAS NO: 181641-61-2
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.38504
• Mol File: 181641-61-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(BENZYLOXYCARBONYL)-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(BENZYLOXYCARBONYL)-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID(181641-61-2)
• EPA Substance Registry System: 1-(BENZYLOXYCARBONYL)-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID(181641-61-2)

Safety Data

• Hazardous Substances Data: 181641-61-2(Hazardous Substances Data)

Usage

Chemical Class

Piperidine carboxylic acids

Appearance

White solid

Uses

a. Precursor in the synthesis of various pharmaceuticals
b. Precursor in the synthesis of other organic compounds

Reactivity

High reactivity and versatility

Importance

a. Serves as an intermediate in the synthesis of complex chemical compounds
b. Used in the production of certain drugs

Structural Features

a. Benzyloxycarbonyl group (C6H5CH2O-CO-)
b. 4-Phenylpiperidine core
c. 4-Carboxylic acid group (-COOH)

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 3627-45-0 4-phenyl-piperidine-4-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 37586-22-4 4-benzoylpiperidine 
• 96067-93-5 benzyl 4-(hydroxydiphenylmethyl)-piperidine-1-carboxylate 
• 916976-36-8 4-benzhydrylidene-piperidine-1-carboxylic acid benzyl ester 
• 922504-27-6 4-benzoylpiperidine-1-carboxylic acid benzyl ester 
• 916976-41-5 4-benzoyl-4-phenyl-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 181641-81-6 1-(Benzyloxycarbonyl)-4-(chloroformyl)-4-phenylpiperidine 
• 674791-72-1 C₂₆H₃₄N₂O₃ 
• 674791-74-3 C₁₈H₃₄N₂O*ClH 
• 674791-73-2 C₁₈H₂₈N₂O*ClH 
• 3627-45-0 4-phenyl-piperidine-4-carboxylic acid 

Relevant articles and documents

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

The invention relates to compounds corresponding to formula (I): in which: Ar represents a mono- or disubstituted phenyl; R1 represents an unsubstituted or substituted phenyl; R2 represents: a pyridyl; an unsubstituted or substituted phenyl; a benzyl that is unsubstituted or substituted on the phenyl; R2 may moreover represent: a heterocyclic radical; R3 represents various values. The invention also comprises methods for the compounds preparation, formulations comprising them and therapeutic applications thereof.

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.

PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS

The invention relates to novel pyridine derivatives of formula 1 and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and their use as neurohormonal antagonists, especially as urotensin II inhibitors.

Ureidopiperidine derivatives as selective human NK3 receptor antagonists

The invention concerns compounds of formula (I) in racemic or optically pure form, methods for obtaining them and pharmaceutical compositions containing same. Said compounds are selective NK3receptor antagonists.

PIPERIDINE DERIVATIVES, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula STR1 used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P-and neurokinin-dependent pathologies.