96067-93-5

Upstream product

• 922504-27-6 4-benzoylpiperidine-1-carboxylic acid benzyl ester 
• 37586-22-4 4-benzoylpiperidine 
• 501-53-1 benzyl chloroformate 
• 1126-09-6 4-carbethoxypiperidine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 115-46-8 C₁₈H₂₁NO 
• 181641-61-2 1-((benzyloxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid 
• 916976-41-5 4-benzoyl-4-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 3627-45-0 4-phenyl-piperidine-4-carboxylic acid 
• 83799-24-0 fexofenadine 
• 105955-84-8 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde 
• 185454-47-1 {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol 
• 916976-36-8 4-benzhydrylidene-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.

Synthesis of terfenadine carboxylate

A synthesis of terfenadine carboxylate, 1, a metabolite of terfenadine 2, is described. In the key step, the sodium salt of 2-(4-bromo-phenyl)-2-methylpropionic acid, 7, was lithiated via a metal-halogen exchange using t-BuLi and subsequently condensed with 4-[4-(hydroxydiphenylmethylpiperidin-1-yl]butyraldehyde, 5, to afford terfenadine carboxylate, 1.