- Recyclable CuO nanoparticles-catalyzed synthesis of novel-2,5-disubstituted 1,3,4-oxadiazoles as antiproliferative, antibacterial, and antifungal agents
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A series of new 2,5-disubstituted 1,3,4-oxadiazoles have been conveniently synthesized through an oxidative C-O coupling by direct C-H bond activation of N-aroyl-N-arylidinehydrazines using a catalytic quantity of CuO nanoparticles. Twenty compounds have been synthesized in good to excellent yields (75-90 %). All the synthesized compounds were evaluated for their in vitro antiproliferative, antibacterial, and antifungal activity. Compounds 8d and 10d are more promising antiproliferative agents with IC50 value of 3.66 and 3.89 μM in MCF-7 cell line, and compounds 8a and 10a were showed more potent antifungal activity than standard drug.
- Murty,Penthala, Raju,Buddana, Sudheer Kumar,Prakasham,Das, Pompi,Polepalli, Sowjanya,Jain,Bojja, Sreedhar
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p. 4579 - 4594
(2016/02/20)
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- Acyl hydrazines as precursors to acyl radicals
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The use of acyl hydrazines (hydrazides) as precursors for the stoichiometric generation of acyl radicals is explored. Two classes of substrates are examined: unsubstituted acyl hydrazines and acyl hydrazines substituted with a leaving group (2-nitrobenzenesulfonyl or 'nosyl'). Both types are successfully converted to acyl radicals, and are then trapped by nitroxide radicals to give acyloxyamine products. Cyclization reactions are demonstrated for both classes of substrates. A low temperature modification of the McFayden-Stevens reaction is also developed.
- Braslau, Rebecca,Anderson, Marc O,Rivera, Frank,Jimenez, Armando,Haddad, Terra,Axon, Jonathan R
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p. 5513 - 5523
(2007/10/03)
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- Intramolecular Cycloaddition Reactions of N-Sulfonyl Nitrile Imides Bearing Alkenyl Groups
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The reaction of the p-tolyl(or phenyl)sulfonylhydrazones of some 2-(alkenyloxy)benzaldehydes with lead tetraacetate leads, via the nitrile imide intermediates, Ar-C(+)=N-N(-)-SO2-C6H4-X-p, to intramolecular 1,3-dipolar cycloadducts and 1-acetyl-2-aroyl-1-
- Shimizu, Tomio,Hayashi, Yoshiyuki,Nagano, Yoshio,Teramura, Kazuhiro
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p. 429 - 434
(2007/10/02)
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