- Four new 9,19-cyclolanostane derivatives from the rhizomes of Cimicifuga yunnanensis hsiao
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Four new 9,19-cyclolanostane-type triterpenes, 24-O-acetyl-25- anhydroshengmanol-3-O-β-d-xylopyranoside (1), 25-i-butylcimigenol-3-O- β-d-xylopyranoside (2), 12-β-hydrocimigenol-3-one (3), and 12-β-hydrocimigenol-1-en-3-one (4), together with 15 known ana
- Nian, Yin,Chen, Jian-Chao,Lu, Lu,Zhang, Xian-Ming,Zhou, Lin,Qiu, Ming-Hua
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Read Online
- Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus
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Cycloartane triterpenoids, 2′,24-O-diacetylisodahurinol-3-O-α- l-arabinopyranoside, 24-O-acetylisodahurinol-3-O-α-l-arabinopyranoside, 12β-hydroxy-25-anhydrocimigenol, cimigenol-12-one, 12β-hydroxy-15- deoxycimigenol, 2′-O-acetyl-24-epi-cimigenol-3-O-α-l- arabinopyranoside, 2′-O-acetylcimigenol-3-O-β-d-xylopyranoside, 25-anhydrocimigenol-3-O-α-l-arabinopyranoside, 2′,23-O- diacetylshengmanol-3-O-α-l-arabinopyranoside, and 2′,24-O-diacetyl- 25-anhydrohydroshengmanol-3-O-α-l-arabinopyranoside, together with eight known compounds, were isolated from aerial parts of Cimicifuga foetida. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines indicated that three of these compounds exhibited broad-spectrum and moderate cytotoxic activities, with IC50 values ranging from 6.20 to 22.74 μM. By comparing previous cytotoxic testing data and bioassay results from this study, preliminary structure-activity relationships of compounds with a cimigenol-skeleton can be proposed.
- Nian, Yin,Zhang, Xian-Min,Li, Yan,Wang, Yuan-Yuan,Chen, Jian-Chao,Lu, Lu,Zhou, Lin,Qiu, Ming-Hua
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experimental part
p. 1473 - 1481
(2012/01/05)
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