Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN
A series of analogs of CRIXIVAN containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.
Coburn, Craig A.,Young, Mary Beth,Hungate, Randall W.,Isaacs, Richard C.A.,Vacca, Joseph P.,Huff, Joel R.
p. 1937 - 1940
(2007/10/03)
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