182317-02-8Relevant articles and documents
Selective inhibitors of glial GABA uptake: Synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues
Falch, Erik,Perregaard, Jens,Fr?lund, Bente,S?kilde, Birgitte,Buur, Anders,Hansen, Lene M.,Frydenvang, Karla,Brehm, Lotte,Bolvig, Tina,Larsson, Orla M.,Sanchez, Connie,White, Harold S.,Schousboe, Arne,Krogsgaard-Larsen, Povl
, p. 5402 - 5414 (2007/10/03)
3-Methoxy-4,5,6,7-tetrahydro-1,2-benzisoxazol-4-one (20a), or the corresponding 3-ethoxy analogue (20b), and 3-chloro- 4,5,6,7-tetrahydro-1,2-benzisothiazol-4-one (51) were synthesized by regioselective chromic acid oxidation of the respective bicyclic te
4-aminotetrahydrobenzisoxazole or -isothiazole compounds
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, (2008/06/13)
The present invention relates to novel 4-aminotetrahydrobenzisoxazoles or 4-aminotetrahydrobenziothiazoles having gamma-aminobutanoic acid (GABA)-uptake inhibiting activity and thus useful in the treatment of analgesia, psychosis, convulsions, anxiety, epileptic disorders or muscular and movement disorders, such as spastic disorders or symptoms in Huntington's disease or Parkinson disease.