Technology Process of 1,2-Benzisoxazole,3-ethoxy-4,5,6,7-tetrahydro-(9CI)
There total 1 articles about 1,2-Benzisoxazole,3-ethoxy-4,5,6,7-tetrahydro-(9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4,5,6,7-tetrahydro-1,2-benz-3-isoxazolol;
With
potassium carbonate;
In
acetone;
at 50 ℃;
for 1h;
ethyl bromide;
In
acetone;
at 50 ℃;
for 1.5h;
DOI:10.1021/jm9904452
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 71 percent / Na2Cr2O7*2H2O; HOAc; conc. H2SO4 / 2 h
2: 98 percent / NaCNBH3; 3 Angstroem molecular sieves / ethanol; methanol / 20 h / 20 °C
3: ET3N / CH2Cl2 / 2 h / 20 °C
With
sodium dichromate; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; acetic acid; triethylamine;
In
methanol; ethanol; dichloromethane;
1: Oxidation / 2: reductive amination / 3: Acylation;
DOI:10.1021/jm9904452
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 71 percent / Na2Cr2O7*2H2O; HOAc; conc. H2SO4 / 2 h
2: 98 percent / NaCNBH3; 3 Angstroem molecular sieves / ethanol; methanol / 20 h / 20 °C
3: ET3N / CH2Cl2 / 2 h / 20 °C
With
sodium dichromate; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; acetic acid; triethylamine;
In
methanol; ethanol; dichloromethane;
1: Oxidation / 2: reductive amination / 3: Acylation;
DOI:10.1021/jm9904452
