182925-45-7

Basic information

• Product Name: 2-(4-METHOXYPHENYL)-3-NITROPYRIDINE
• Synonyms: 2-(4-METHOXYPHENYL)-3-NITROPYRIDINE
• CAS NO: 182925-45-7
• Molecular Formula: C₁₂H₁₀N₂O₃
• Molecular Weight: 230.22
• Mol File: 182925-45-7.mol

Chemical Properties

• Melting Point: 88-92
• Appearance: /
• CAS DataBase Reference: 2-(4-METHOXYPHENYL)-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXYPHENYL)-3-NITROPYRIDINE(182925-45-7)
• EPA Substance Registry System: 2-(4-METHOXYPHENYL)-3-NITROPYRIDINE(182925-45-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 182925-45-7(Hazardous Substances Data)

Usage

Type of compound

Organic chemical compound (specifically, a nitroaromatic compound)

Structure

Contains a pyridine ring and a methoxyphenyl group

Usage

Commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Physical properties

Yellow crystalline solid with a high melting point and low solubility in water

Reactivity

Exhibits reactivity in various organic reactions due to its nitro and methoxy functional groups, and can be used as a building block for the synthesis of more complex molecules

Safety precautions

Should be handled and stored with caution due to its potential hazards as a nitro compound.

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 663918-44-3 2-(4-methoxyphenyl)pyridine-3-amino 

Relevant articles and documents

Visible-light-driven Cadogan reaction

Visible-light-driven photochemical Cadogan-type cyclization has been discovered. The organic D-A type photosensitizer 4CzIPN found to be an efficient mediator to transfer energy from photons to the transient intermediate that breaks the barriers of deoxygenation in Cadogan reaction and enables a mild metal-free access to carbazoles and related heterocycles. DFT calculation results indicate mildly endergonic formation of the intermediate complex of nitrobiarenes and PPh3, which corresponds with experimental findings regarding reaction temperature. The robust synthetic capacity of the photoredox Cadogan reaction systems has been demonstrated by the viable productivity of a broad range of carbazoles and related N-heterocycles with good tolerance of various functionalities.

Solvent-free synthesis of δ-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent

A green and efficient preparation of functionalized δ-carbolines/ carbazoles via reductive ring closure by 1,2-bis(dipenylphosphino)ethane under solvent-free conditions is described. The starting materials 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives are readily prepared through Suzuki-Miyaura cross-coupling reaction from commercially available compounds. And the polar by-product ethane-1,2-diylbis(diphenylphosphine oxide) is easily removed from the relatively polar reaction mixture. Various substituted δ-carbolines/carbazoles are obtained in acceptable yields. It is particularly worth mentioning that substrates with electron-withdrawing groups (EWG) also give the desired products in good yield.

PHENYLPYRIDINE COMPOUND AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

A phenylpyridine compound represented by the formula has an excellent controlling activity against plant diseases: [, wherein, in the formula, R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom and the like; R6 represents a hydrogen atom or a C1-C3 alkyl group; R7, R8 and R11 independently represent a hydrogen atom, a halogen atom and the like; R9 and R10 independently represent a hydroxyl group and the like; W1―W2=W3 ―W4 represents N―CH=CH―CH and the like; X represents an oxygen atom and the like; and Q represents a (C1-C6 alkoxy)methylene and the like].