183158-34-1Relevant articles and documents
Method for synthesizing alpha-BPDA
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, (2022/03/31)
The invention discloses a method for synthesizing alpha-BPDA, which comprises the following steps: by taking 2, 3-methyl bromobenzene and N-methyl-4-chlorophthalimide as raw materials, dissolving 2, 3-methylaniline in dichloromethane, salifying by adopting sulfuric acid, carrying out diazotization reaction, washing, concentrating and recrystallizing to obtain 2, 3-methyl bromobenzene, and preparing 2, 3-BPDA by adopting an Mg/tributyl borate system. The preparation method comprises the following steps: carrying out a Suzuki coupling reaction on 2, 3-methylphenylboronic acid and N-methyl-4-chlorophthalimide to obtain 5-(2, 3-dimethylphenyl)-2-methylisoindole-1, 3-diketone, carrying out alkaline hydrolysis and oxidation through a sodium hydroxide and potassium permanganate system to prepare 2, 3, 3 ', 4'-biphenyl tetracarboxylic acid, and finally forming anhydride in an o-xylene system to obtain the high-purity alpha-BPDA. According to the synthesis method, the problems of low yield and environmental pollution caused by the fact that products in a traditional method are all three isomeric mixtures are solved.
Substituted phenyl farnesyltransferase inhibitors
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, (2012/09/25)
Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
A novel method for the synthesis of substituted naphthalenes and phenanthrenes
De Koning, Charles B.,Michael, Joseph P.,Rousseau, Amanda L.
, p. 787 - 797 (2007/10/03)
A new method for the synthesis of substituted naphthalenes and phenanthrenes was discussed. A formal synthesis of tanshinone I was also studied. Natural products that contain a naphthalene or phenanthrene nucleus often exhibit biological activity, which makes them attractive targets in organic synthesis. The results showed that the reaction can be proceed through at least two different pathways.