183158-34-1

Basic information

• Product Name: 2,3-Dimethylphenylboronic acid
• Synonyms: AKOS BRN-0096;2,3-DIMETHYLBENZENEBORONIC ACID;2,3-DIMETHYLPHENYLBORONIC ACID;RARECHEM AH PB 0184;O-XYLENE-3-BORONIC ACID;2,3-Dimethylphenylboronic;2,3-DIMETHYLBENZENEBORONIC ACID 98%;2,3-Dimethylphenylboronic Acid (contains varying amounts of Anhydride)
• CAS NO: 183158-34-1
• Molecular Formula: C₈H₁₁BO₂
• Molecular Weight: 149.98
• EINECS: -0
• Product Categories: blocks;BoronicAcids;Boronic Acid series;Aryl;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Boronic acid;Boronic Acids;Boronic Acids and Derivatives
• Mol File: 183158-34-1.mol

Chemical Properties

• Melting Point: 174-180 °C(lit.)
• Boiling Point: 312.6 °C at 760 mmHg
• Flash Point: 142.8 °C
• Appearance: White/Crystalline Powder
• Density: 1.07 g/cm³
• Vapor Pressure: 0.000224mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: 8.70±0.58(Predicted)
• BRN: 8050763
• CAS DataBase Reference: 2,3-Dimethylphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dimethylphenylboronic acid(183158-34-1)
• EPA Substance Registry System: 2,3-Dimethylphenylboronic acid(183158-34-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36/37-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 183158-34-1(Hazardous Substances Data)

Usage

Uses

Used in Polymer Industry:
2,3-Dimethylphenylboronic acid is used as a monomer for the synthesis of novel asymmetric dianhydrides, which are essential in the preparation of thermoset and thermoplastic polyimides. These polyimides are derived from asym. dianhydrides such as 2,3,3'',4'' benzophenone dianhydride (a-BTDA) and 3,4''-(hexafluoroisopropylidene)diphthalic anhydride (a-6FDA). The use of 2,3-Dimethylphenylboronic acid in this application contributes to the development of advanced materials with improved properties for various applications, including aerospace, electronics, and automotive industries.

InChI:InChI=1/C8H11BO2/c1-6-4-3-5-8(7(6)2)9(10)11/h3-5,10-11H,1-2H3

Upstream product

• 576-23-8 2,3-dimethylbromobenzene 
• 5419-55-6 Triisopropyl borate 
• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 121-43-7 Trimethyl borate 
• 87-59-2 2,3-Dimethylaniline 

Downstream Products

• 217468-56-9 1-Methyl-2-(2,3-dimethylphenyl)-1H-indole-3-carbaldehyde 
• 852146-17-9 5-(2,3-dimethylphenyl)furan-2-carboxylic acid methyl ester 
• 852122-06-6 (+/-)-{[5-chloro-7-(2,3-dimethylphenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}amine 
• 852122-82-8 (+/-)-{[7-(2,3-dimethylphenyl)-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}amine 
• 852123-31-0 (+/-)-{[7-(2,3-dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}amine 
• 936841-42-8 2-(2,3-dimethylphenyl)-N-(2-phenylpropan-2-yl)benzenesulfonamide 
• 213381-68-1 2-methyl-7-(2,3-dimethylphenyl)-1-indanone 
• 2657-15-0 3,4,2',3'-tetramethylbenzophenone 
• 1092384-68-3 2-chloro-3-(2,3-dimethylphenyl)pyridine 
• 1092384-67-2 3-chloro-2-(2,3-dimethylphenyl)pyridine 

Relevant articles and documents

Method for synthesizing alpha-BPDA

The invention discloses a method for synthesizing alpha-BPDA, which comprises the following steps: by taking 2, 3-methyl bromobenzene and N-methyl-4-chlorophthalimide as raw materials, dissolving 2, 3-methylaniline in dichloromethane, salifying by adopting sulfuric acid, carrying out diazotization reaction, washing, concentrating and recrystallizing to obtain 2, 3-methyl bromobenzene, and preparing 2, 3-BPDA by adopting an Mg/tributyl borate system. The preparation method comprises the following steps: carrying out a Suzuki coupling reaction on 2, 3-methylphenylboronic acid and N-methyl-4-chlorophthalimide to obtain 5-(2, 3-dimethylphenyl)-2-methylisoindole-1, 3-diketone, carrying out alkaline hydrolysis and oxidation through a sodium hydroxide and potassium permanganate system to prepare 2, 3, 3 ', 4'-biphenyl tetracarboxylic acid, and finally forming anhydride in an o-xylene system to obtain the high-purity alpha-BPDA. According to the synthesis method, the problems of low yield and environmental pollution caused by the fact that products in a traditional method are all three isomeric mixtures are solved.

Substituted phenyl farnesyltransferase inhibitors

Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

A novel method for the synthesis of substituted naphthalenes and phenanthrenes

A new method for the synthesis of substituted naphthalenes and phenanthrenes was discussed. A formal synthesis of tanshinone I was also studied. Natural products that contain a naphthalene or phenanthrene nucleus often exhibit biological activity, which makes them attractive targets in organic synthesis. The results showed that the reaction can be proceed through at least two different pathways.