- 2-hydroxy-3-hydroxyethoxy-N,N-dimethyldodecyl ammonium chloride synthesis novel method
-
The invention discloses a 2-hydroxy-3-hydroxyethoxy-N,N-dimethyldodecyl ammonium chloride synthesis novel method. The method adopts the following technical scheme: A, in a stirring reactor with a reflux device, measured ethanol, epichlorohydrin and diisopropylamine are added; the temperature is increased to 60-80 DEG; ethylene glycol is dropped in slowly; the temperature is maintained, and a reaction is carried out for 4-10h, such that a 3-chloro-2-hydroxyethoxypropanol reaction product is obtained; B, water and N,N-dimethyldodecyl tertiary amine are added into the reaction product obtained in the step A; the temperature is maintained at 70-80 DEG C, and a reaction is carried out for 2-4h; heating is carried out, and the reaction system is subjected to a reflux reaction for 2-4h; the reaction is finished, the solvent is recycled under reduced pressure, and white waxy solid 2-hydroxy-3-hydroxyethoxy-N,N-dimethyldodecyl ammonium chloride is obtained. The method provided by the invention has the advantages of simple operation, mild reaction, high conversion rate, and low cost. The solvent and catalyst adopted by the invention can be repeatedly utilized.
- -
-
Paragraph 0010
(2016/11/17)
-
- 2-Hydroxymethyl-1,4-dioxane: Synthesis, resolution and determination of the absolute configurations of the enantiomers
-
2-Hydroxymethyl-1, 4-dioxane 3 was resolved via salt formation between its hydrogen phthalate and (R)- or (S)-1-phenylethylamine, selective crystallization of the resultant diastereomeric mixtures and subsequent recovery of its enantiomers by saponification. The progress of the resolution was followed by chiral HPLC and the absolute stereochemistry of the two enantiomers determined by comparison of their specific rotations with that of (R)-3 synthesized from enantiomerically pure (R)-1-O-benzylglycerol. The results of the synthesis of 3 and of its resolution are discussed and compared with those previously obtained for 1,2-isopropylidene glycerol evaluating the consequences of replacement of ispropylidene with an ethylene bridge.
- Pallavicini, Marco,Valoti, Ermanno,Villa, Luigi
-
p. 267 - 273
(2007/10/03)
-
- Synthesis of Aminomethyl Crown Ethers
-
Various N-substituted or unsubstituted aminomethyl crown ethers, which possess a reactive amino group, were prepared in good yields by the reaction between 3-amino-1,2-propanediols or aminomethyl oligoethylene glycols and oligoethylene glycol ditosylates or dichlorides.The scope of the reaction was investigated and the complexing ability of these new crown ether derivatives with sodium and potassium ions in methanol was measured by potentiometric titration.
- Maeda, Hirokazu,Kikui, Takashi,Nakatsuji, Yohji,Okahara, Mitsuo
-
p. 5167 - 5171
(2007/10/02)
-