18371-74-9

Basic information

• Product Name: 1-chloro-3-(2-hydroxyethoxy)propan-2-ol
• Synonyms: 1-chloro-3-(2-hydroxyethoxy)propan-2-ol;1-Chloro-3-(2-hydroxyethoxy)-2-propanol;1-Chloro-3-(2-hydroxyethyl)-2-propanol;2-Propanol, 1-chloro-3-(2-hydroxyethyl)-;Brn 1361549;Einecs 242-248-4;U 27,967
• CAS NO: 18371-74-9
• Molecular Formula: C₅H₁₁ClO₃
• Molecular Weight: 154.59204
• EINECS: 242-248-4
• Mol File: 18371-74-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 294.1°Cat760mmHg
• Flash Point: 131.7°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 0.000174mmHg at 25°C
• Refractive Index: 1.472
• PKA: 13.18±0.20(Predicted)
• CAS DataBase Reference: 1-chloro-3-(2-hydroxyethoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-(2-hydroxyethoxy)propan-2-ol(18371-74-9)
• EPA Substance Registry System: 1-chloro-3-(2-hydroxyethoxy)propan-2-ol(18371-74-9)

Safety Data

• Hazardous Substances Data: 18371-74-9(Hazardous Substances Data)

Usage

Physical State

Colorless liquid
The compound is in a liquid state and is colorless, which may aid in its usage in various applications.

Odor

Mild, sweet
The compound has a pleasant, mild odor that may be less irritating to work with compared to chemicals with strong or unpleasant smells.

Usage

Solvent, production of other chemicals
As a solvent, it can dissolve other substances, and its ability to produce other chemicals makes it valuable in various chemical reactions.

Applications

Manufacturing of pharmaceuticals, resins, and other organic compounds
The compound serves as an intermediate in the synthesis of various products, including medications, plastics, and other organic materials.

Additional Uses

Cleaning agent, production of surfactants, synthesis of pesticides and herbicides
Its versatility extends to cleaning purposes, creating surfactants, and producing agricultural chemicals like pesticides and herbicides.

InChI:InChI=1/C5H11ClO3/c6-3-5(8)4-9-2-1-7/h5,7-8H,1-4H2

Upstream product

• 106-89-8 epichlorohydrin 
• 75-21-8 oxirane 
• 96-24-2 3-monochloro-1,2-propanediol 
• 107-21-1 ethylene glycol 

Downstream Products

• 14641-24-8 1,2-dihydroxy-3-(2-hydroxyethoxy)propane 
• 109563-24-8 1-(2-hydroxy-ethoxy)-3-(N-methyl-p-anisidino)-propan-2-ol 
• 83585-56-2 2-aminomethyl-15-crown-5 
• 83585-61-9 2-(aminomethyl)-18-crown-6 
• 29908-11-0 (+/-)-2-(hydroxymethyl)-1,4-dioxane 
• 28544-95-8 3,6-dioxa-1-cycloheptanol 
• 100252-91-3 1-p-anisidino-3-(2-hydroxy-ethoxy)-propan-2-ol 
• 10525-62-9 Glycerin-1-aethyl-3β-hydroxy-aethyldiaether 
• 105788-36-1 acetic acid-{4-[2-hydroxy-3-(2-hydroxy-ethoxy)-propoxy]-anilide} 
• 406913-89-1 Phthalic acid mono-(R)-1-[1,4]dioxan-2-ylmethyl ester 
• 406913-91-5 Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester 
• 406913-84-6 2-hydroxymethyl-1,4-dioxane hydrogen phthalate 
• 406913-93-7 [(2S)-1,4-dioxan-2-yl]methanol 
• 406913-88-0 (R)-(-)-2-hydroxymethyl-1,4-dioxane 

Relevant articles and documents

2-hydroxy-3-hydroxyethoxy-N,N-dimethyldodecyl ammonium chloride synthesis novel method

The invention discloses a 2-hydroxy-3-hydroxyethoxy-N,N-dimethyldodecyl ammonium chloride synthesis novel method. The method adopts the following technical scheme: A, in a stirring reactor with a reflux device, measured ethanol, epichlorohydrin and diisopropylamine are added; the temperature is increased to 60-80 DEG; ethylene glycol is dropped in slowly; the temperature is maintained, and a reaction is carried out for 4-10h, such that a 3-chloro-2-hydroxyethoxypropanol reaction product is obtained; B, water and N,N-dimethyldodecyl tertiary amine are added into the reaction product obtained in the step A; the temperature is maintained at 70-80 DEG C, and a reaction is carried out for 2-4h; heating is carried out, and the reaction system is subjected to a reflux reaction for 2-4h; the reaction is finished, the solvent is recycled under reduced pressure, and white waxy solid 2-hydroxy-3-hydroxyethoxy-N,N-dimethyldodecyl ammonium chloride is obtained. The method provided by the invention has the advantages of simple operation, mild reaction, high conversion rate, and low cost. The solvent and catalyst adopted by the invention can be repeatedly utilized.

Synthesis of Aminomethyl Crown Ethers

Various N-substituted or unsubstituted aminomethyl crown ethers, which possess a reactive amino group, were prepared in good yields by the reaction between 3-amino-1,2-propanediols or aminomethyl oligoethylene glycols and oligoethylene glycol ditosylates or dichlorides.The scope of the reaction was investigated and the complexing ability of these new crown ether derivatives with sodium and potassium ions in methanol was measured by potentiometric titration.