- Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules
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A series of twelve fluorescently labeled amino acids were designed by assembling different coumarin, fluorescein, or nitrobenzo-furazan fluorophores with N-protected lysine or 2-aminopropionic acid. The synthesized amino acids were evaluated with regard to their spectroscopic properties. The easy introduction of the amino acids into peptides and peptidomimetics was exemplarily shown for one coumarin-labeled- amino acid.
- H?u?ler, Daniela,Gütschow, Michael
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p. 245 - 255
(2016/01/15)
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- Photodegradable groups for tunable polymeric materials
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Provided is a method that provides both spatial and temporal control of a polymer degradation process using mono- and multifunctional macromolecular monomers (“macromers”) that degrade via single- and multi-photon photolysis mechanisms over a broad range
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Page/Page column 17-18
(2013/02/28)
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- Photodegradable hydrogels to generate positive and negative features over multiple length scales
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Here we present a photodegradable hydrogel as a biocompatible, nonfouling photoresist capable of presenting positive and negative features through single-photon and two-photon degradation. An ortho-nitrobenzylether (o-NBE) moiety is used as a polymerizabl
- Wong, Darice Y.,Griffin, Donald R.,Reed, Jason,Kasko, Andrea M.
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experimental part
p. 2824 - 2831
(2011/10/09)
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- Synthesis and characterization of new 3-acyl-7-hydroxy-6,8-substituted- coumarin and 3-acyl-7-benzyloxy-6,8-substituted-coumarin derivatives
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(Chemical Equation Presented) A new series of 3-acyl-6,7,8-substituted coumarin derivatives has been synthesized in high yields (79-99%) and characterized by means of elemental analysis, mass spectrometry, IR, and 1H NMR spectroscopy. We examined with particular attention the presence of an acyl group at position 3 (ethyl ester, carboxylic acid, and acyl chloride), and of a hydroxyl group at position 7 or a functionalized one like benzyloxy or phthalimido. The hydroxyl group has been modified by an etherification in presence of crown ether with substituted benzyl bromide or chloride to evaluate the influence on chemical characteristics and lipophilicity of coumarin nucleus. Halogens (Cl, Br) and methyl group were introduced in position 6 and 8 of the coumarin ring, respectively, in order to study their effect on reaction feasibility. Some of these 3-acyl derivatives have been recently assayed as MAO inhibitors and as intermediates (i.e. reactive chloride derivative) to design new anti-Helicobacter pylori agents.
- Chimenti, Franco,Bolasco, Adriana,Secci, Daniela,Bizzarri, Bruna,Chimenti, Paola,Granese, Arianna,Carradori, Simone
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experimental part
p. 729 - 733
(2010/08/22)
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- Synthesis and photochemical properties of a light-activated fluorophore to label His-tagged proteins
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Rapid and efficient light-induced fluorescence enhancement is demonstrated on a DMNPB-"caged" coumarin derivative carrying a His-tag recognition motif. The Royal Society of Chemistry.
- Orange, Clelia,Specht, Alexandre,Puliti, David,Sakr, Elias,Furuta, Toshiaki,Winsor, Barbara,Goeldner, Maurice
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p. 1217 - 1219
(2008/12/21)
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- Promiscuous G-protein compositions and their use
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Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.
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- Photo-caged fluorescent molecules
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A class of photo-caged and cell permeable fluorescent molecules having high uncaging cross sections, robust fluorescence enhancement, and flexible chemistry for bioconjugation. Some of the photo-caged fluorescent molecules are derived from 6-chloro-7-hydroxy-coumarin 3-carboxamide. The fluorescent molecules are useful for cellular imaging applications and particularly for tracing the molecular transfer between cellular gap junctions. The fluorescent molecules also have an emission wavelength that spectrally complements with the emission wavelength of other fluorophores, enabling simultaneous multi-color imaging.
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- New Caged Coumarin Fluorophores with Extraordinary Uncaging Cross Sections Suitable for Biological Imaging Applications
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Photocaged fluorescent molecules are important research tools for tracking molecular dynamics with high spatiotemporal resolution in biological systems. We have designed and synthesized a new class of caged coumarin fluorophores. These coumarin cages disp
- Zhao, YuRui,Zheng, Quan,Dakin, Kenneth,Xu, Ke,Martinez, Manuel L.,Li, Wen-Hong
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p. 4653 - 4663
(2007/10/03)
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