- A GENERAL METHOD FOR THE PREPARATION OF 2,2,4-TRIMETHYL AND 2,2-DIMETHYL-4-ISOPROPYL-6-HYDROXY-7-SUBSTITUTED CHROMANS
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2,2,4-Trimethyl and 2,2-dimethyl-4-isopropyl-6-hydroxy-7-substituted chromans can be conveniently prepared by the reaction of 2-substituted hydroquinones with 2-methyl-2,4-pentanediol or 2,5-dimethyl-2,5-hexanediol, respectively, in the presence of macroreticular strongly acidic sulfonic acid cation exchange resin catalysts.The reaction is positionally selective and allows for simple workups and reasonable yields.
- Eubanks, J. R. I.,Pacifici, J. G.
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p. 829 - 836
(2007/10/02)
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- Process for producing 2,2,4-trimethyl-6-hydroxy-7-substituted chromans
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A process for producing 2,2,4-trimethyl-6-hydroxy-7-substituted chromans which comprises reacting 2-substituted hydroquinones with 2-methyl-2,4-pentanediol in the presence of a Friedel-Crafts catalyst.
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