184416-84-0

Basic information

• Product Name: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID
• Synonyms: 2,3-DICHLOROISONICOTINIC ACID;2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID;2,3-dichloroisonicotic acid;2,3-Dichloropyridine-4-carboxylic acid, 4-Carboxy-2,3-dichloropyridine;2,3- twochlorineisonicotinic acid
• CAS NO: 184416-84-0
• Molecular Formula: C₆H₃Cl₂NO₂
• Molecular Weight: 192
• EINECS: 1592732-453-0
• Product Categories: Pyridines
• Mol File: 184416-84-0.mol

Chemical Properties

• Melting Point: 187°
• Boiling Point: 413.576 °C at 760 mmHg
• Flash Point: 203.924 °C
• Appearance: /Solid
• Density: 1.612 g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.46±0.28(Predicted)
• CAS DataBase Reference: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID(184416-84-0)
• EPA Substance Registry System: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID(184416-84-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 184416-84-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dichloropyridine-4-carboxylic acid is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Pesticide Industry:
In the pesticide industry, 2,3-Dichloropyridine-4-carboxylic acid is employed as a key component in the formulation of certain pesticides. Its chemical properties contribute to the effectiveness of these products in controlling pests and protecting crops.
Used in Dye Industry:
2,3-Dichloropyridine-4-carboxylic acid is used as a raw material in the production of dyes. Its chemical composition enables the creation of a wide range of colors and hues, making it a valuable asset in the dye industry.
Safety Precautions:

InChI:InChI=1/C6H3Cl2NO2/c7-4-3(6(10)11)1-2-9-5(4)8/h1-2H,(H,10,11)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 124-38-9 carbon dioxide 
• 184416-82-8 2,3-dichloroisonicotinonitrile 

Downstream Products

• 603124-78-3 methyl 2,3-dichloroisonicotinate 
• 329794-25-4 (2,3- dichloropyridin-4-yl)methanol 
• 885167-89-5 3-chloro-2-methoxyisonicotinaldehyde 
• 1222185-17-2 dimethyl 3-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylate 

Relevant articles and documents

8-ANILIN0IMIDAZ0PYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS

The invention relates to imidazopyridines of formula I with anti -cancer and/or anti- inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperprolif erative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (Formula I)

PYRIMIDONE COMPOUND

A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof:wherein R1 represents a C1-C12 alkyl; R2 represents a hydrogen atom or the like; R3 represents a halogen or the like; q represents an integer of 1 to 7; R4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R5 represents a C6-C10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

Strategies for the selective functionalization of dichloropyridines at various sites

Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.

Pyridine compounds which are useful as pesticides

A pyridine derivative of the formula (I), or its oxide or salt: STR1 wherein R1 is a halogen atom, an alkyl group, etc., R2 is an alkenyl group, an alkynyl group, an alkoxycarbonyl group, an alkenyloxycarbonyl group, etc., R3/s