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CAS

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184488-19-5

(S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE, also known as (S)-Fluoxetine epoxide, is a chemical compound utilized in the synthesis of pharmaceuticals. It is an epoxide, characterized by a three-membered ring with oxygen, and features a fluorophenoxy group, which includes a benzene ring connected to a fluorine atom and a methoxy group. (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE serves as a crucial intermediate in the production of the antidepressant fluoxetine, commonly known as Prozac.

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  • 184488-19-5 Structure

  • Basic information

    1. Product Name: (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE
    2. Synonyms: (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE
    3. CAS NO:184488-19-5
    4. Molecular Formula: C9H9FO2
    5. Molecular Weight: 168.1649632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 184488-19-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 246.1±10.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.218±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE(184488-19-5)
    11. EPA Substance Registry System: (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE(184488-19-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 184488-19-5(Hazardous Substances Data)

184488-19-5 Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE is used as an intermediate for the synthesis of various medications, primarily for the treatment of mental health conditions. Its role in the production of fluoxetine, an antidepressant, highlights its importance in developing effective treatments for depression and related disorders.
Used in Antidepressant Medication:
In the pharmaceutical industry, (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE is used as a key component in the synthesis of fluoxetine, an antidepressant medication. It contributes to the development of this medication, which is widely prescribed for the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, and several other mental health conditions.
Used in the Synthesis of Other Medications:
Beyond its application in the production of fluoxetine, (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE is also utilized as a building block in the synthesis of other medications targeting mental health conditions. Its versatility as a chemical intermediate makes it a valuable asset in the pharmaceutical industry for creating a range of therapeutic options.

Check Digit Verification of cas no

The CAS Registry Mumber 184488-19-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,4,8 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 184488-19:
(8*1)+(7*8)+(6*4)+(5*4)+(4*8)+(3*8)+(2*1)+(1*9)=175
175 % 10 = 5
So 184488-19-5 is a valid CAS Registry Number.

184488-19-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE

1.2 Other means of identification

Product number -
Other names Fmoc-L-3-Cyanophenylalanine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:184488-19-5 SDS

184488-19-5Relevant articles and documents

Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands

Van Niel, Monique B.,Beer, Margaret S.,Castro, Jose L.,Cheng, Susan K.F.,Evans, David C.,Heald, Anne,Hitzel, Laure,Hunt, Peter,Mortishire-Smith, Russell,O'Connor, Desmond,Watt, Alan P.,MacLeod, Angus M.

, p. 3243 - 3248 (1999)

A solution phase synthesis for the preparation of 3-aryloxy-2-propanolamine libraries has been developed. This resulted in the identification of 5 as a ligand with dual affinity for 5-HT(1A) and serotonin re-uptake receptors which shows excellent pharmacokinetic parameters.

LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE

-

Page/Page column 39, (2008/12/07)

Novel β1 adrenoreceptor ligands that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging) are provided. Methods of imaging, including methods of imaging congestive heart failure, are also provide

Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes

Peukert, Stefan,Jacobsen, Eric N.

, p. 1245 - 1248 (2008/02/09)

(matrix presented) The kinetic resolution of epoxides with phenols catalyzed by a polymer-supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries. The corresponding 1-aryloxy-2-alcohols are obtained i

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