18451-70-2

Basic information

• Product Name: (E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one
• Synonyms: (E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one
• CAS NO: 18451-70-2
• Molecular Formula: C₁₄H₁₀N₂O₃
• Molecular Weight: 254
• Mol File: 18451-70-2.mol

Chemical Properties

• Melting Point: 182-184 °C
• Boiling Point: 422.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• PKA: 2.77±0.10(Predicted)
• CAS DataBase Reference: (E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one(18451-70-2)
• EPA Substance Registry System: (E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one(18451-70-2)

Safety Data

• Hazardous Substances Data: 18451-70-2(Hazardous Substances Data)

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1041868-02-3 (E)-3-(4-aminophenyl)-1-(pyridin-3-yl)prop-2-en-1-one 

Relevant articles and documents

Role of direction of charge transfer on the nonlinear optical behavior of pyridine substituted chalcone derivatives

High quality single crystals of an efficient novel nonlinear optical (NLO) chalcone derivative 3-(4-nitrophenyl)-1-(pyridine-3-yl) prop-2-en-1-one (4NP3AP) that are transparent in the entire visible and infrared region are grown by the slow evaporation so

Cinnamoyl inhibitors of tissue transglutaminase

(Figure Presented) Transglutaminases (TGases) catalyze the intermolecular cross-linking of certain proteins and tissue TGases (TG2) are involved in diverse biological processes. Unregulated, high TGase activities have been implicated in several physiological disorders, but few reversible inhibitors of TG2 have been reported. Herein, we report the synthesis of a series of novel trans-cinammoyl derivatives, discovered to be potent inhibitors of guinea pig liver transglutaminase. The most effective inhibitors evaluated can be sorted into two subclasses: substituted cinnamoyl benzotriazolyl amides and the 3-(substituted cinnamoyl)pyridines, referred to more commonly as azachalcones. Kinetic evaluation of both of these subclasses revealed that they display reversible inhibition and are competitive with acyl donor TGase substrates at IC50 values as low as 18 μM. An analysis of structure - activity relationships within these series of inhibitors permitted the identification of potentially important binding interactions. Further testing of some of the most potent inhibitors demonstrated their selectivity for TG2 and their potential for further development.

CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE

A compound of Formula, (I) or Formula: (II)