cas 18474-60-7, 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID | Articles data ｜lookchem

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18474-60-7

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The first potent and selective non-imidazole human histamine H4 receptor antagonists
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.
Jablonowski, Jill A.,Grice, Cheryl A.,Chai, Wenying,Dvorak, Curt A.,Venable, Jennifer D.,Kwok, Annette K.,Ly, Kiev S.,Wei, Jianmei,Baker, Sherry M.,Desai, Pragnya J.,Jiang, Wen,Wilson, Sandy J.,Thurmond, Robin L.,Karlsson, Lars,Edwards, James P.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
p. 3957 - 3960
(2007/10/03)

INDOLOYLGUANIDINE DERIVATIVES
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-
(2008/06/13)

More Articles about upstream products of 18474-60-7

70761-93-2
ethyl 7-methyl-1H-indole-2-carboxylate

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Chemical Properties

Melting Point: 169-175 °C
Boiling Point: 413.3 °C at 760 mmHg
Flash Point:203.8 °C
Density: 1.34 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 1.43E-07mmHg at 25°C
Refractive Index: 1.696
PKA: 4.48±0.30(Predicted)
PSA: 53.09000
LogP: 2.17450

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