18474-60-7 Usage
Uses
Different sources of media describe the Uses of 18474-60-7 differently. You can refer to the following data:
1. ? ;Reactant for preparation of N-terminal anthranoyl-phenylalanine derivatives as CCK1 receptor antagonists1? ;Reactant for preparation of factor Xa inhibitors based on a 2-carboxyindole scaffold2? ;Reactant for preparation of potent and selective non-imidazole human histamine H4 receptor antagonists3
2. 7-Methyl-1h-Indole-2-Carboxylic Acid is used in prepaation of novel oxalyl piperazines active against the hepatitis B virus (HBV).
Check Digit Verification of cas no
The CAS Registry Mumber 18474-60-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,7 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 18474-60:
(7*1)+(6*8)+(5*4)+(4*7)+(3*4)+(2*6)+(1*0)=127
127 % 10 = 7
So 18474-60-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2/c1-6-3-2-4-7-5-8(10(12)13)11-9(6)7/h2-5,11H,1H3,(H,12,13)
18474-60-7Relevant articles and documents
The first potent and selective non-imidazole human histamine H4 receptor antagonists
Jablonowski, Jill A.,Grice, Cheryl A.,Chai, Wenying,Dvorak, Curt A.,Venable, Jennifer D.,Kwok, Annette K.,Ly, Kiev S.,Wei, Jianmei,Baker, Sherry M.,Desai, Pragnya J.,Jiang, Wen,Wilson, Sandy J.,Thurmond, Robin L.,Karlsson, Lars,Edwards, James P.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 3957 - 3960 (2007/10/03)
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.
