184968-88-5

Basic information

• Product Name: 1-Boc-4-piperidin-1-ylMethyl-piperidine
• Synonyms: 1-Boc-4-piperidin-1-ylMethyl-piperidine
• CAS NO: 184968-88-5
• Molecular Formula: C₁₆H₃₀N₂O₂
• Molecular Weight: 282.4216
• Mol File: 184968-88-5.mol

Chemical Properties

• Boiling Point: 366.697°C at 760 mmHg
• Flash Point: 175.572°C
• Appearance: /
• Density: 1.024g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.497
• PKA: 9.63±0.10(Predicted)
• CAS DataBase Reference: 1-Boc-4-piperidin-1-ylMethyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-piperidin-1-ylMethyl-piperidine(184968-88-5)
• EPA Substance Registry System: 1-Boc-4-piperidin-1-ylMethyl-piperidine(184968-88-5)

Safety Data

• Hazardous Substances Data: 184968-88-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H30N2O2/c1-16(2,3)20-15(19)18-11-7-14(8-12-18)13-17-9-5-4-6-10-17/h14H,4-13H2,1-3H3

Upstream product

• 110-89-4 piperidine 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 6457-49-4 4-piperidinemethanol 
• 184968-83-0 4-(2-oxo-piperidin-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 32470-52-3 4-(piperidin-1-yl)methyl-piperidine 
• 1089279-22-0 1-[3-(methyloxy)-4-nitrophenyl]-4-(1-piperidinylmethyl)piperidine 

Relevant articles and documents

Imidazopyridine Kinase Inhibitors

The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

DIAMINE DERIVATIVE

The present invention provides a diamine derivative or the like represented by the general formula (I): {wherein Q represents an oxygen atom or the like, RG represents a hydrogen atom or the like, RI represents (wherein p and r may be the same or different, and each represents 0 or the like, RA represents a hydrogen atom or the like, and RB and Rc may be the same or different, and each represents a hydrogen atom or the like), RH represents a hydrogen atom or the like, and RJ represents: (wherein q and s may be the same or different, and each represents 0 or the like, RD represents a hydrogen atom or the like, and RE and RF may be the same or different, and each represents a hydrogen atom or the like) or the like}, etc.

SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS

Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) or (e); R is methyl or ethyl; and Z is substituted piperidinyl.

Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)- (methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.