185022-12-2 Usage
Uses
Used in Bioconjugation:
Aminooxy-PEG2-alcohol is used as a bioconjugation agent for the formation of oxime or hydroxylamine linkages with aldehyde-containing biomolecules. Its ability to form stable covalent bonds makes it a valuable tool in the development of novel bioconjugates for various applications in research and therapeutics.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Aminooxy-PEG2-alcohol is used as a component in the design of drug delivery systems. Its reactive groups facilitate the attachment of drug molecules to the PEG linker, enhancing the solubility, stability, and bioavailability of the drug. This can lead to improved therapeutic outcomes and reduced side effects.
Used in Diagnostics:
Aminooxy-PEG2-alcohol can be utilized in the development of diagnostic tools, such as imaging agents or biosensors, due to its ability to form stable bonds with target molecules. The PEG linker provides a flexible and biocompatible platform for the attachment of various functional groups, making it suitable for a wide range of diagnostic applications.
Used in Material Science:
In the field of material science, Aminooxy-PEG2-alcohol can be employed in the synthesis of novel biocompatible materials, such as hydrogels or surface coatings, by taking advantage of its reactive groups for covalent attachment to other molecules or surfaces. This can lead to the development of advanced materials with tailored properties for various applications, including tissue engineering and regenerative medicine.
Used in Chemical Synthesis:
Aminooxy-PEG2-alcohol can be used as a building block in the synthesis of complex organic molecules, particularly in the field of medicinal chemistry. Its reactive aminooxy and hydroxyl groups allow for the incorporation of various functional groups, enabling the development of new compounds with potential therapeutic or diagnostic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 185022-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,0,2 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 185022-12:
(8*1)+(7*8)+(6*5)+(5*0)+(4*2)+(3*2)+(2*1)+(1*2)=112
112 % 10 = 2
So 185022-12-2 is a valid CAS Registry Number.
185022-12-2Relevant articles and documents
2'-Deoxy-2'-alkoxyaminouridines: Novel 2'-substituted uridines prepared by intramolecular nucleophilic ring opening of 2,2'-O-anhydrouridines
Sebesta, David P.,O'Rourke, Sarah S.,Martinez, Rogelio L.,Pieken, Wolfgang A.,McGee, Danny P. C.
, p. 14385 - 14402 (2007/10/03)
Natural and unnatural modified nucleosides and nucleotides play important roles in biology, medicine, and as biomedical research tools. Reported herein is an application of synthetic methodology developed for the stereo- and regiospecific introduction of structural modifications at the 2'-position of uridine nucleosides. A novel class of modified nucleosides, 2'-alkoxylamino-2'-deoxy uridines, are prepared by intramolecular nucleophilic addition of a 3'-tethered alkoxycarbamate nucleophile to the 2'-position with concomitant opening of a 2,2'-anhydrouridine.
