Aminooxy-PEG2-alcohol

Base Information

• Chemical Name: Aminooxy-PEG2-alcohol
• CAS No.: 185022-12-2
• Molecular Formula: C4H11NO3
• Molecular Weight: 121.136
• Mol file: 185022-12-2.mol

Synonyms:2-(2-Aminooxy-ethoxy)-ethanol;

Chemical Property of Aminooxy-PEG2-alcohol

Chemical Property:

• Boiling Point: 265.9±20.0 °C(Predicted)
• PKA: 14.39±0.10(Predicted)
• PSA: 64.71000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: -0.41410

Purity/Quality:

97% ^*data from raw suppliers

Aminooxy-PEG2-alcohol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Aminooxy-PEG2-alcohol is a short PEG linker containing an aminooxy group and a a hydroxyl group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Technology Process of Aminooxy-PEG2-alcohol

There total 1 articles about Aminooxy-PEG2-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(2-(2-hydroxyethoxy)ethoxy)isoindoline-1,3-dione (185022-23-5) → diglycolamine (185022-12-2)

Guidance literature:

With hydrazine hydrate; In methanol; for 1h;

DOI:10.1016/0040-4020(96)00870-8

Reference yield: 70.0%

4,4′-[1,4-phenylenebis(methyleneoxy)]bisbenzaldehyde (64621-41-6) + diglycolamine (185022-12-2) → C30H36N2O6

Guidance literature:

In N,N-dimethyl-formamide; at 105 ℃; for 6h; Inert atmosphere;

DOI:10.1007/s11696-018-0525-4

Reference yield:

diglycolamine (185022-12-2) + Imidazole-1-carboxylic acid (2R,3R,3aS,9aR)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-yl ester → 5'-O-(4,4'-dimethoxytrityl)-3'-O-[2-(2-hydroxyethoxy)ethoxyamino]carbonyl-2,2'-O-anhydrouridine (185022-17-7)

Guidance literature:

With pyridine; Yield given;

DOI:10.1016/0040-4020(96)00870-8

upstream raw materials:

2-(2-(2-hydroxyethoxy)ethoxy)isoindoline-1,3-dione

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-3'-O-[2-(2-hydroxyethoxy)ethoxyamino]carbonyl-2,2'-O-anhydrouridine

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