185040-35-1

Basic information

• Product Name: 4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde
• Synonyms: 4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde;4-(ethylamino)-2-(methylthio)-5-Pyrimidinecarboxaldehyde;4-Ethylamino-2-methanethiopyrimidine-5-carboxaldehyde
• CAS NO: 185040-35-1
• Molecular Formula: C₈H₁₁N₃OS
• Molecular Weight: 197.25744
• EINECS: -0
• Mol File: 185040-35-1.mol

Chemical Properties

• Melting Point: 58-61 °C
• Boiling Point: 384.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 3.07±0.10(Predicted)
• CAS DataBase Reference: 4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde(185040-35-1)
• EPA Substance Registry System: 4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde(185040-35-1)

Safety Data

• Hazardous Substances Data: 185040-35-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-(ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde is used as a research compound to explore its interactions with biological systems. Its pharmacological activity and potential to modulate biological pathways make it a valuable tool for understanding the mechanisms of action of new drug candidates.
Used in Drug Development:
4-(ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde is utilized in drug development to create novel therapeutic agents. Its ability to be modified and incorporated into various chemical structures allows for the design of drugs with specific target profiles, potentially leading to the discovery of new treatments for various diseases and conditions.
Used in Organic Chemistry:
In the realm of organic chemistry, 4-(ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde serves as a valuable compound for further exploration and research. Its unique properties and reactivity make it an interesting subject for studies on chemical reactions, synthesis strategies, and the development of new organic compounds with potential applications in various industries.

Upstream product

• 185040-34-0 (4-ethylamino-2-methanesulfanyl-pyrimidin-5-yl)-methanol 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 75-04-7 ethylamine 
• 185040-33-9 4-ethylamino-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 185039-74-1 6-(2,6-dichlorophenyl)-8-ethyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-ylideneamine 
• 185039-76-3 6-(2,6-dichlorophenyl)-8-ethyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1011463-82-3 N-ethyl-5-((4-fluoro-3-nitrophenylamino)methyl)-2-(methylthio)pyrimidin-4-amine 
• 211244-82-5 8-ethyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 211245-16-8 8-ethyl-2-(4-hydroxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211245-12-4 8-ethyl-2-(4-methoxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 

Relevant articles and documents

Chemically Diverse Group i p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

p21-activated kinase 1 (PAK1) has an important role in transducing signals in several oncogenic pathways. The concept of inhibiting this kinase has garnered significant interest over the past decade, particularly for targeting cancers associated with PAK1 amplification. Animal studies with the selective group I PAK (pan-PAK1, 2, 3) inhibitor G-5555 from the pyrido[2,3-d]pyrimidin-7-one class uncovered acute toxicity with a narrow therapeutic window. To attempt mitigating the toxicity, we introduced significant structural changes, culminating in the discovery of the potent pyridone side chain analogue G-9791. Mouse tolerability studies with this compound, other members of this series, and compounds from two structurally distinct classes revealed persistent toxicity and a correlation of minimum toxic concentrations and PAK1/2 mediated cellular potencies. Broad screening of selected PAK inhibitors revealed PAK1, 2, and 3 as the only overlapping targets. Our data suggest acute cardiovascular toxicity resulting from the inhibition of PAK2, which may be enhanced by PAK1 inhibition, and cautions against continued pursuit of pan-group I PAK inhibitors in drug discovery.

PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS

This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to, cancer.

Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7- oxo-7,8-dihydro-pyrido[2,3- d ]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5)

The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure-activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl- piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6- carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30-100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure-activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound.

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl) propylamino]-8-methyl-8 H -pyrido[2,3- d ]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2 H -pyran-4-ylamino)pyrido[2,3- d ]pyrimidin-7(8 H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase

The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.

KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

A facile, KF/Al2O3 mediated method for the preparation of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones

A series of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones were prepared by a KF/Al2O3 mediated condensation of 4-(alkylamino)-2-(methylthio)pyrimidine-5-carbaldehydes and phenyl acetic acid ester derivatives.

Pyridopyrimidinone derivatives for treatment of neurodegenerative disease

This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferatives disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2 (amino and thio)pyrido[2,3-d]pyrimidines and 2,4-di

6-ALKOXY-PYRIDO-PYRIMIDINES AS P-38 MAP KINASE INHIBITORS

The present invention provides compounds of Formula (I), wherein R1 is alkyl, cycloalkyl, cycloakylalkyl, or -CH2-alkenyl, X1 is O, NH, N(alkyl), S or -C(=O), Z is N or CH; and R2 and R3 are as define

2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimdin-7-ones

This invention provides antiangiogenic compounds of the Formula (I), which are useful for treating diseases, resulting from uncontrolled cellular proliferation such as cancer, atherosclerosis, rheumatoid arthritis, and psoriasis. 1

6-Substituted pyrido-pyrimidines

The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.