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(S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID, commonly known as L-Phenylalanine, is an essential amino acid that is naturally present in protein-rich foods. It is crucial for the synthesis of other amino acids, neurotransmitters, and proteins within the human body. L-Phenylalanine plays a significant role in mood regulation, appetite control, and stress response management. Moreover, it is utilized as a dietary supplement and is under investigation for its potential therapeutic effects on various conditions, including depression, chronic pain, and attention deficit disorder.

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  • 185062-84-4 Structure
  • Basic information

    1. Product Name: (S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID
    2. Synonyms: L-HOMOTYROSINE;(S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID
    3. CAS NO:185062-84-4
    4. Molecular Formula: C10H13NO3
    5. Molecular Weight: 195.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 185062-84-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 397 °C at 760 mmHg
    3. Flash Point: 193.9 °C
    4. Appearance: /
    5. Density: 1.281 g/cm3
    6. Vapor Pressure: 5.13E-07mmHg at 25°C
    7. Refractive Index: 1.598
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: (S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID(185062-84-4)
    12. EPA Substance Registry System: (S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID(185062-84-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 185062-84-4(Hazardous Substances Data)

185062-84-4 Usage

Uses

Used in Pharmaceutical Industry:
L-Phenylalanine is used as an active pharmaceutical ingredient for the treatment of certain medical conditions. Its role in neurotransmitter synthesis makes it a potential candidate for the management of mood disorders and other neurological conditions.
Used in Dietary Supplements:
L-Phenylalanine is utilized as a dietary supplement to support the body's natural production of neurotransmitters and proteins. It is particularly beneficial for individuals with specific dietary restrictions or those seeking to enhance their mood, appetite, and stress response.
Used in Nutraceutical Industry:
In the nutraceutical industry, L-Phenylalanine is incorporated into health products and supplements that aim to improve cognitive function, emotional well-being, and overall health. Its potential therapeutic benefits make it a valuable component in the development of nutraceutical formulations.
Used in Research and Development:
L-Phenylalanine is extensively studied in research settings for its potential therapeutic applications in various conditions. Ongoing research is focused on understanding its mechanisms of action and exploring its potential synergistic effects with other compounds in the treatment of depression, chronic pain, and attention deficit disorder.
Used in Food and Beverage Industry:
L-Phenylalanine is sometimes used in the food and beverage industry as a flavor enhancer or to improve the nutritional profile of certain products. Its presence in protein-rich foods makes it a natural choice for enhancing the amino acid content of various food items.

Check Digit Verification of cas no

The CAS Registry Mumber 185062-84-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,0,6 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 185062-84:
(8*1)+(7*8)+(6*5)+(5*0)+(4*6)+(3*2)+(2*8)+(1*4)=144
144 % 10 = 4
So 185062-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO3/c11-9(10(13)14)6-3-7-1-4-8(12)5-2-7/h1-2,4-5,9,12H,3,6,11H2,(H,13,14)/t9-/m0/s1

185062-84-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-AMINO-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID

1.2 Other means of identification

Product number -
Other names L-HOMOTYROSINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:185062-84-4 SDS

185062-84-4Relevant articles and documents

Method for Preparing Unnatural Amino Acids

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Paragraph 0172; 0173; 0208; 0209, (2017/01/09)

The present invention relates to a manufacturing method of unnatural amino acids and unnatural amino acids manufactured thereby. Specifically, the present invention relates to an asymmetric synthesis method which can manufacture unnatural amino acids having significantly high optical purity, and to the unnatural amino acids manufactured thereby. A manufacturing method of unnatural amino acids represented by chemical formula 6 or chemical formula 7 comprises the steps of: synthesizing a compound represented by chemical formula 4 or chemical formula 5; manufacturing a diol compound; and manufacturing a carboxylic acid compound.COPYRIGHT KIPO 2016

Inhibition of tyrosine phenol-lyase by tyrosine homologues

Do, Quang,Nguyen, Giang T.,Phillips, Robert S.

, p. 2243 - 2251 (2016/08/26)

We have designed, synthesized, and evaluated tyrosine homologues and their O-methyl derivatives as potential inhibitors for tyrosine phenol lyase (TPL, E.C. 4.1.99.2). Recently, we reported that homologues of tryptophan are potent inhibitors of tryptophan indole-lyase (tryptophanase, TIL, E.C. 4.1.99.1), with Ki values in the low μM range (Do et al. Arch Biochem Biophys 560:20–26, 2014). As the structure and mechanism for TPL is very similar to that of TIL, we postulated that tyrosine homologues could also be potent inhibitors of TPL. However, we have found that homotyrosine, bishomotyrosine, and their corresponding O-methyl derivatives are competitive inhibitors of TPL, which exhibit Ki values in the range of 0.8–1.5?mM. Thus, these compounds are not potent inhibitors, but instead bind with affinities similar to common amino acids, such as phenylalanine or methionine. Pre-steady-state kinetic data were very similar for all compounds tested and demonstrated the formation of an equilibrating mixture of aldimine and quinonoid intermediates upon binding. Interestingly, we also observed a blue-shift for the absorbance peak of external aldimine complexes of all tyrosine homologues, suggesting possible strain at the active site due to accommodating the elongated side chains.

Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91)

Zi, Jiachen,Lantvit, Daniel D.,Swanson, Steven M.,Orjala, Jimmy

, p. 173 - 177 (2012/03/27)

Two anabaenopeptin-type peptides, lyngbyaureidamides A and B, together with two previously reported peptides lyngbyazothrins C and D, were isolated from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91). Their structures were determined by spectroscopic and chemical methods. Lyngbyazothrins C and D were also able to inhibit the 20S proteasome with IC50 values of 7.1 μM and 19.2 μM, respectively, while lyngbyaureidamides A and B were not active at 50 μM.

Comparisons of O-acylation and Friedel-Crafts acylation of phenols and acyl chlorides and Fries rearrangement of phenyl esters in trifluoromethanesulfonic acid: Effective synthesis of optically active homotyrosines

Murashige, Ryo,Hayashi, Yuka,Ohmori, Syo,Torii, Ayuko,Aizu, Yoko,Muto, Yasuyuki,Murai, Yuta,Oda, Yuji,Hashimoto, Makoto

, p. 641 - 649 (2011/03/19)

Reactions involving phenol derivatives and acyl chlorides have to be controlled for competitive O-acylations and C-acylations (Friedel-Crafts acylations and Fries rearrangements) in acidic condition. The extent for these reactions in trifluoromethanesulfonic acid (TfOH), which is used as catalyst and solvent, is examined. Although diluted TfOH was needed for effective O-acylation, concentrated TfOH was required for effective C-acylations in mild condition. These results have been applied to the novel synthesis of homotyrosine derivatives. Both Fries rearrangement of N-TFA-Asp(OBn)-OMe and Friedel-Crafts acylation of phenol with N-TFA-Asp(Cl)-OMe in TfOH afforded the homotyrosine skeleton, followed by reduction and deprotection afforded homotyrosines maintaining stereochemistry of Asp as an optically pure form.

Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8

Okumura, Hilary S.,Philmus, Benjamin,Portmann, Cyril,Hemscheidt, Thomas K.

supporting information; experimental part, p. 172 - 176 (2009/06/27)

Two homotyrosine-bearing cyanopeptolins are described from Planktothrix agardhii CYA 126/8. The compounds feature a common homotyrosine-containing cyclohexadepsipeptide and differ by sulfation of an exocyclically located 2-O-methyl-D-glyceric acid residue. In addition we describe two anabaenopeptins, which contain two homotyrosine residues, one of which is N-methylated. The anabaenopeptins have a common cyclopentapeptide portion and differ in the amino acid linked to it via an ureido bond, arginine and tyrosine, respectively.

Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides

Matthew, Susan,Paul, Valerie J.,Luesch, Hendrik

experimental part, p. 2058 - 2063 (2010/07/04)

The Floridian marine cyanobacterium Lyngbya confervoides afforded cyclodepsipeptides, termed tiglicamides A-C (1-3), along with their previously reported analogues largamides A-C (4-6), all of which possess an unusual tiglic acid moiety. Their structures

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

Wang, Weibo,Li, Qun,Hasvold, Lisa,Steiner, Beth,Dickman, Daniel A.,Ding, Hong,Clairborne, Akyio,Chen, Hui-Ju,Frost, David,Goldman, Robert C.,Marsh, Kennan,Hui, Yu-Hua,Cox, Brian,Nilius, Angela,Balli, Darlene,Lartey, Paul,Plattner, Jacob J.,Bennani, Youssef L.

, p. 489 - 493 (2007/10/03)

The echinocandin class of cyclic lipopepetides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.

Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes

Long, Alan,Baldwin, Steven W.

, p. 5343 - 5345 (2007/10/03)

A new two-step route to derivatives of homophenylalanine is presented. Cycloaddition of a cyclic nitrone glycine template with various styrene derivatives affords good yields of 5-substituted cycloadducts. One-step hydrogenolysis (three bonds) then affords the optically pure α-amino acids related to homophenylalanine.

Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: Tests with novel side chains and with several agonists

Kearney, Patrick C.,Nowak, Mark W.,Zhong, Wenge,Silverman, Scott K.,Lester, Henry A.,Dougherty, Dennis A.

, p. 1401 - 1412 (2007/10/03)

Structure-function relations in the nicotinic acetylcholine receptor are probed using a recently developed method based on chemical synthesis of nonsense suppressor tRNAs with unnatural amino acid residues, site-directed incorporation at nonsense codons in Xenopus laevis oocytes, and electrophysiological measurements. A broad range of unnatural amino acids, as many as 14 at a given site, are incorporated at three sites, α93, α190, and α198, all of which are tyrosine in the wild-type receptor and are thought to contribute to the agonist binding site. Confirming and expanding upon earlier studies using conventional mutagenesis, the three tyrosines are shown to be in substantially different structural microenvironments. In particular, a crucial role is established for the hydroxyl group of α-Tyr93, whereas a variety of substituents are functional at the analogous position of αTyr198. Interestingly, consideration of three different agonists (acetylcholine, nicotine, and tetramethylammonium) does not discriminate between these two best-characterized binding site residues. In addition, double-mutation studies establish the independent effects of mutations at the pore region (second transmembrane region) and at the agonist binding site, and this observation leads to a novel strategy for adjusting EC50 values. These results establish the broad generality and great potential of the unnatural amino acid methodology for illuminating subtle structural distinctions in neuroreceptors and related integral membrane proteins.

HYDROXYLATION REACTION OF AROMATIC RINGS IN AQUEOUS SOLUTION INDUCED BY HYDROGEN-OXYGEN FLAME

Takasaki, Michiaki,Nomoto, Shinya,Harada, Kaoru

, p. 1629 - 1632 (2007/10/02)

It was found that direct hydroxylation of aromatic rings proceeded in aqueous solution of phenyl-containing amino acids by using hydrogen-oxygen flame and that the active species of the reaction could be considered as hydroxyl radicals generated in the burning flame.

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