- Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids
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ω-[(4Z)-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4H)-imidazol-
- Topuzyan,Kazoyan,Tamazyan,Aivazyan,Galstyan, L. Kh.
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p. 1369 - 1377
(2018/11/21)
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- A phosphine-catalyzed preparation of 4-Arylidene-5-imidazolones
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A simple and efficient method for constructing 4-arylidene-5-imidazolones was developed using a phosphinecatalyzed tandem umpolung addition and intramolecular cyclization of amidine pronucleophiles on arylpropiolates. The reaction offers a robust route to heterocycle analogues of the fluorescent protein chromophores. (Chemical Equation Presented).
- Gabillet, Sandra,Loreau, Olivier,Specklin, Simon,Rasalofonjatovo, Evelia,Taran, Frdric
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p. 9894 - 9898
(2015/01/09)
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- Efficient microwave-assisted synthesis and antioxidant activity of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones
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The efficient synthesis of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones was achieved via microwaveassisted reactions of 4-arylmethylene-2-phenyloxazol-5(4H) -ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type
- Shi, Feng,Zeng, Xiao-Ning,Wu, Fei-Yue,Yan, Shu,Zheng, Wei-Fa,Tu, Shu-Jiang
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experimental part
p. 59 - 63
(2012/04/23)
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- Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones
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(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.
- Gong, Xiaoyu,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Zhao, Yufen,Fu, Hua
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supporting information; experimental part
p. 3128 - 3131
(2010/09/04)
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- Derivatives of α,β-dehydro amino acids: III. Reaction of 4-arylmethylidene-4,5-dihydro-1,3-oxazol-5-ones with hexamethyldisilazane
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4-Arylmethylidene-4,5-dihydro-1,3-oxazol-5-ones reacted with hexamethyldisilazane in ethyl acetate, acetonitrile, or DMF at room temperature to give mainly 2-acylamino-3-arylmethylideneprop-2-enamides, whereas in boiling DMF the corresponding 4-arylmethyl
- Topuzyan,Arutyunyan,Oganesyan
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p. 868 - 871
(2008/03/11)
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- Novel, selective mechanism-based inhibitors of the herpes proteases
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A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyl oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been sh
- Pinto, Ivan L.,West, Andrew,Debouck, Christine M.,DiLella, Anthony G.,Gorniak, Joselina G.,O'Donnell, Kevin C.,O'Shannessy, Daniel J.,Patel, Arunbai,Jarvest, Richard L.
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p. 2467 - 2472
(2007/10/03)
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- Condensation of unsaturated azlactones with urea and thiourea: Some observations
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4-Arylmethyleneoxazol-5-ones (1c,d) on condensation with urea/thiourea form the corresponding imidazol-5-ones (4c,d), whereas 4-cyclohexylideneoxazol-5-one (1e) gives 2-cyclohexylideneacetamido (5).A plausible mechanism has been discussed.
- Mukerjee, Arya K.,Joseph, Kiran,Homami, Sayed Saied,Sanjayan, Gangadhar J.
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p. 973 - 974
(2007/10/02)
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- Reactions of Some 1,3-Diaminonucleophiles with Azlactones
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Triethylamine-mediated reactions of S-substituted isothiuronium halides (2) with unsaturated azlactones (1) gave the corresponding S-substituted 2-thiopyrimidines (3), S-substituted 3-thioacrylanilide (10), and 4-benzylidene-2-iminoimidazolidin-5-one (13)
- Tikdari, Ahmad M.,Tripathy, Pradeep K.,Mukerjee, Arya K.
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p. 1659 - 1662
(2007/10/02)
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- Synthesis of Acylamino Acids and Acylamino Acid Amides by Simultaneous Reduction and Hydrolysis of Unsaturated 2,4-Disubstituted 2-Imidazolin-5-ones
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Twelve acylamino acids (II) and two acylamino acid amides (III) have been prepared by the simultaneous reduction and hydrolysis of unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) with a mixture of zinc dust and potassium hydroxide solution.
- Devasia, Ganapathiplackal M.,Shafi, P. Mohamed
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p. 204 - 206
(2007/10/02)
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- Synthesis of some New Derivatives of Imidazole Compounds
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The reaction of 1-substituted-2-phenyl-4-arylidine-5-imidazolones with different nucleophilic reagents has been studied.The new compounds synthesised showed certain biological activities.
- El-Maghraby, M. A.,El-Ela, A. Abou,Khalafalla, A. K.,El-Shami, E.
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p. 676 - 680
(2007/10/02)
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- The Luminescence Spectroscopic Properties and the Electronic Structure of Certain Derivatives of Azlactones and Azlactams
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The luminescence spectroscopic properties of azlactones and their structural analogues (azlactams) in toluene have been investigated.The dipole moments in the ground and excited states have been measured and compared with the calculated values.
- Krasovitskii, B. M.,Afanasiadi, L. Sh.,Lysova, I. V.,Stryukov, M. B.,Lyubarskaya, A. E.
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p. 1519 - 1522
(2007/10/02)
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- Synthesis of Acylamino Acid Amides and Acylamino Acids via 2,4-Disubstituted 2-Imidazolin-5-ones
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Unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) have been reduced with a mixture of hydriodic acid and red phosphorus in the presence of acetic anhydride to give the saturated 2,4-disubstituted 2-imidazolin-5-ones (II) which have been hydrolysed to acylamino acid amides (III) and acylamino acids (IV) with sodium hydroxide solution under different conditions.In all six acylamino acid amides (23 - 51percent yields) and four acylamino acids (26 - 65percent yields) have been prepared.One saturated 2-imidazolin-5-one, namely 2-phenyl-4-benzyl-2-imidazolin-5-one has been isolated from the reaction in 40percent yield and identified.
- Devasia, Ganapathiplackal M.,Shafi, P. Mohamed
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