18511-00-7Relevant academic research and scientific papers
Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids
Topuzyan,Kazoyan,Tamazyan,Aivazyan,Galstyan, L. Kh.
, p. 1369 - 1377 (2018/11/21)
ω-[(4Z)-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4H)-imidazol-
A phosphine-catalyzed preparation of 4-Arylidene-5-imidazolones
Gabillet, Sandra,Loreau, Olivier,Specklin, Simon,Rasalofonjatovo, Evelia,Taran, Frdric
, p. 9894 - 9898 (2015/01/09)
A simple and efficient method for constructing 4-arylidene-5-imidazolones was developed using a phosphinecatalyzed tandem umpolung addition and intramolecular cyclization of amidine pronucleophiles on arylpropiolates. The reaction offers a robust route to heterocycle analogues of the fluorescent protein chromophores. (Chemical Equation Presented).
Efficient microwave-assisted synthesis and antioxidant activity of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones
Shi, Feng,Zeng, Xiao-Ning,Wu, Fei-Yue,Yan, Shu,Zheng, Wei-Fa,Tu, Shu-Jiang
experimental part, p. 59 - 63 (2012/04/23)
The efficient synthesis of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones was achieved via microwaveassisted reactions of 4-arylmethylene-2-phenyloxazol-5(4H) -ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type
Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones
Gong, Xiaoyu,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Zhao, Yufen,Fu, Hua
supporting information; experimental part, p. 3128 - 3131 (2010/09/04)
(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.
Derivatives of α,β-dehydro amino acids: III. Reaction of 4-arylmethylidene-4,5-dihydro-1,3-oxazol-5-ones with hexamethyldisilazane
Topuzyan,Arutyunyan,Oganesyan
, p. 868 - 871 (2008/03/11)
4-Arylmethylidene-4,5-dihydro-1,3-oxazol-5-ones reacted with hexamethyldisilazane in ethyl acetate, acetonitrile, or DMF at room temperature to give mainly 2-acylamino-3-arylmethylideneprop-2-enamides, whereas in boiling DMF the corresponding 4-arylmethyl
Novel, selective mechanism-based inhibitors of the herpes proteases
Pinto, Ivan L.,West, Andrew,Debouck, Christine M.,DiLella, Anthony G.,Gorniak, Joselina G.,O'Donnell, Kevin C.,O'Shannessy, Daniel J.,Patel, Arunbai,Jarvest, Richard L.
, p. 2467 - 2472 (2007/10/03)
A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyl oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been sh
Condensation of unsaturated azlactones with urea and thiourea: Some observations
Mukerjee, Arya K.,Joseph, Kiran,Homami, Sayed Saied,Sanjayan, Gangadhar J.
, p. 973 - 974 (2007/10/02)
4-Arylmethyleneoxazol-5-ones (1c,d) on condensation with urea/thiourea form the corresponding imidazol-5-ones (4c,d), whereas 4-cyclohexylideneoxazol-5-one (1e) gives 2-cyclohexylideneacetamido (5).A plausible mechanism has been discussed.
Reactions of Some 1,3-Diaminonucleophiles with Azlactones
Tikdari, Ahmad M.,Tripathy, Pradeep K.,Mukerjee, Arya K.
, p. 1659 - 1662 (2007/10/02)
Triethylamine-mediated reactions of S-substituted isothiuronium halides (2) with unsaturated azlactones (1) gave the corresponding S-substituted 2-thiopyrimidines (3), S-substituted 3-thioacrylanilide (10), and 4-benzylidene-2-iminoimidazolidin-5-one (13)
Synthesis of Acylamino Acids and Acylamino Acid Amides by Simultaneous Reduction and Hydrolysis of Unsaturated 2,4-Disubstituted 2-Imidazolin-5-ones
Devasia, Ganapathiplackal M.,Shafi, P. Mohamed
, p. 204 - 206 (2007/10/02)
Twelve acylamino acids (II) and two acylamino acid amides (III) have been prepared by the simultaneous reduction and hydrolysis of unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) with a mixture of zinc dust and potassium hydroxide solution.
