1851373-36-8 Usage
Uses
Used in Pharmaceutical Industry:
CPD1548 is used as an anticancer agent for its ability to inhibit the KDM4 histone demethylase, which is involved in the regulation of gene expression and is often dysregulated in cancer cells. By targeting this enzyme, CPD1548 has the potential to suppress tumor growth and serve as a therapeutic intervention in cancer treatment.
Used in Drug Development:
CPD1548 is used as a lead compound in the development of novel cancer therapies. Its antiproliferative effects make it a promising candidate for further research and development, with the potential to be optimized and incorporated into new drug formulations for the treatment of various types of cancer.
Used in Cancer Research:
CPD1548 is used as a research tool to study the role of KDM4 histone demethylase in cancer biology. By understanding the molecular mechanisms underlying its antiproliferative effects, researchers can gain valuable insights into the development of targeted cancer therapies and identify potential biomarkers for the diagnosis and prognosis of cancer.
Used in Drug Delivery Systems:
Similar to gallotannin, CPD1548 can also benefit from novel drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles can be employed as carriers for CPD1548 delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1851373-36-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,5,1,3,7 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1851373-36:
(9*1)+(8*8)+(7*5)+(6*1)+(5*3)+(4*7)+(3*3)+(2*3)+(1*6)=178
178 % 10 = 8
So 1851373-36-8 is a valid CAS Registry Number.
1851373-36-8Relevant articles and documents
KDM4 INHIBITORS
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Paragraph 00143; 00144, (2018/10/25)
The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
Chen, Young K.,Bonaldi, Tiziana,Cuomo, Alessandro,Del Rosario, Joselyn R.,Hosfield, David J.,Kanouni, Toufike,Kao, Shih-Chu,Lai, Chon,Lobo, Neethan A.,Matuszkiewicz, Jennifer,McGeehan, Andrew,O'Connell, Shawn M.,Shi, Lihong,Stafford, Jeffrey A.,Stansfield, Ryan K.,Veal, James M.,Weiss, Michael S.,Yuen, Natalie Y.,Wallace, Michael B.
, p. 869 - 874 (2017/08/16)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The modulat
