66361-67-9

Basic information

• Product Name: 6-BROMO-TETRAL-1-ON
• Synonyms: 6-BROMO-TETRAL-1-ON;6-BROMOTETRALONE;6-Bromo-1-tetralone;6-BROMO-A-TETRALONE;6-Bromotetral-1-one;1(2H)-Naphthalenone, 6-broMo-3,4-dihydro-
• CAS NO: 66361-67-9
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• Mol File: 66361-67-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 40-42℃
• Boiling Point: 116°C/0.05mmHg(lit.)
• Flash Point: 111.44 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Toluene
• Sensitive: Light Sensitive
• CAS DataBase Reference: 6-BROMO-TETRAL-1-ON(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-TETRAL-1-ON(66361-67-9)
• EPA Substance Registry System: 6-BROMO-TETRAL-1-ON(66361-67-9)

Safety Data

• Hazardous Substances Data: 66361-67-9(Hazardous Substances Data)

Usage

Uses

6-bromo-1-tetralone used in Wittig-Horner reaction.

InChI:InChI=1/C10H9BrO/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h4-6H,1-3H2

Upstream product

• 3470-50-6 6-Hydroxy-1-tetralone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 228256-58-4 6-bromo-1,2,3,4-tetrahydronaphthalen-1-ol 
• 19936-14-2 1-(4-bromophenyl)cyclobutan-1-ol 
• 589-87-7 1,4-bromoiodobenzene 
• 524-38-9 N-hydroxyphthalimide 
• 35333-26-7 4-bromo-δ-oxobenzenepentanoic acid 
• 88611-67-0 6-acetamido-1,2,3,4-tetrahydronaphthalen-1-one 
• 3470-53-9 6-amino-1-tetralone 

Downstream Products

• 76043-03-3 6-Bromo-2-[hydroxy-(1-phenylsulfanyl-cyclopropyl)-methyl]-3,4-dihydro-2H-naphthalen-1-one 
• 76042-21-2 2-<(1-((2,6-dimethoxyphenyl)thio)cyclopropyl)hydroxymethyl>-6-bromo-3,4-dihydronaphthalen-1(2H)-one 
• 741721-26-6 (S)-N-(2,4-dimethoxy-benzyl)-N-[2-oxo-3-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-oxazolidin-5-ylmethyl]-acetamide 
• 1426082-27-0 2-chloro-6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol 
• 1426082-26-9 6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol 
• 1378382-85-4 (6-bromo-3,4-dihydro-naphthalen-1-yloxy)-triisopropyl-silane 

Relevant articles and documents

Regioselective Electrochemical Cyclobutanol Ring Expansion to 1-Tetralones

A mild electrochemical method for the regioselective preparation of 1-tetralones under environmentally friendly conditions from readily available cyclobutanols was developed. A series of aromatic- and heteroaromatic-fused 1-tetralones was accessed through ring expansion of the functionalized cyclobutanols via electrochemical generation of alkoxy radicals and intramolecular cyclization.

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

KDM4 INHIBITORS

The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.