- NOVEL CANNABINOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION
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The present invention relates to compounds of f formula (I) as cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2 ) receptor modulators, and uses thereof f or treating diseases, conditions and/or disorders modulated by a cannabinoid receptor ( such as pain, neurodegenrative disorders, eating disorders, weight loss or control, and obesity).
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Page/Page column 28-29
(2009/05/30)
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- On the tautomerism of cinnolin-4-ol, cinnoline-4-thiol, and cinnolin-4-amine
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Detailed NMR spectroscopic investigations (1H, 13C, 15N) with cinnolin-4-ol (1) reveal this compound to exist exclusively in the cinnolin-4(1H)-one form in deuteriodimethyl sulfoxide solution. This finding is confirmed by comparison of the NMR spectroscopic data of 1 with those of the corresponding 'fixed' O-methyl and N-methyl derivatives, i.e. 4-methoxycinnoline (3) and 1-methylcinnolin-4(1H)-one (5). Similarly, cinnoline-4-thiol (4) is present in the thione form in deuteriodimethyl sulfoxide, whereas cinnolin-4-amine (7) exists in the amino form. In addition, in-depth analyses of the NMR spectra of some simple 4-substituted cinnolines are provided.
- Holzer, Wolfgang,Eller, Gernot A.,Schoenberger, Simeon
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- A New Facile Synthesis of 4-Oxo-1,4-dihydrocinnolines
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2-(2-Aminoaryl)-2-oxo-triphenylphosphoniumethylides 2a-d, readily available by standard procedures, are converted into 4-oxo-1,4-dihydrocinnolines 7a-d by treatment with nitrous acid and subsequent basic hydrolysis of the intermediate phosphoranes 6a-d.
- Baldoli, Clara,Licandro, Emanuela,Maiorana, Stefano,Menta, Ernesto,Papagni, Antonio
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p. 288 - 290
(2007/10/02)
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